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Accuracy of colposcopy in the Swedish screening program

INTRODUCTION: Sensitivity and specificity of colposcopy vary greatly between studies and efficacy in clinical studies seldom corresponds with effectiveness in a real‐life setting. It is unclear whether colposcopists’ experience affects assessment; studies show divergent results. The study's obj...

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Autores principales: Alfonzo, Emilia, Zhang, Chenyang, Daneshpip, Forogh, Strander, Björn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10072243/
https://www.ncbi.nlm.nih.gov/pubmed/36879505
http://dx.doi.org/10.1111/aogs.14538
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author Alfonzo, Emilia
Zhang, Chenyang
Daneshpip, Forogh
Strander, Björn
author_facet Alfonzo, Emilia
Zhang, Chenyang
Daneshpip, Forogh
Strander, Björn
author_sort Alfonzo, Emilia
collection PubMed
description INTRODUCTION: Sensitivity and specificity of colposcopy vary greatly between studies and efficacy in clinical studies seldom corresponds with effectiveness in a real‐life setting. It is unclear whether colposcopists’ experience affects assessment; studies show divergent results. The study's objective was to investigate the accuracy of colposcopies in the Swedish screening program, the variability in colposcopists’ assessments and whether degree of experience affects accuracy in a routine setting. MATERIAL AND METHODS: Cross‐sectional register study. All colposcopic assessments with a concomitant histopathological sample from women aged at least 18 years, performed between 1999 and September 2020 in Sweden. The main outcome measure was accuracy. The accuracy of colposcopic assessments was calculated as overall agreement with linked biopsies, with three outcomes: Normal vs Atypical, Normal vs Low‐Grade Atypical vs High‐Grade Atypical, and Non‐High‐Grade Atypical vs High‐Grade Atypical. A time‐trend analysis was performed. The accuracy of identifiable colposcopists related to experience was analyzed. RESULTS: In total, 82 289 colposcopic assessments with linked biopsies were included for analysis of the outcome Normal vs Atypical; average accuracy was 63%. Overrating colposcopic findings was four times more common than underrating. No time trend in accuracy was noted during the study period. Accuracy in distinguishing High‐Grade from Non‐High‐Grade lesions was better: 76%. Among identifiable colposcopists, overall accuracy was 67%. Some had significantly better accuracy than others, but no correlation with experience was found. CONCLUSIONS: Colposcopy, including in a referral setting, has low accuracy in distinguishing Normal from Atypical. Increased experience alone does not lead to improvement. This is supported by the substantial differences in performance between colposcopists.
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spelling pubmed-100722432023-04-05 Accuracy of colposcopy in the Swedish screening program Alfonzo, Emilia Zhang, Chenyang Daneshpip, Forogh Strander, Björn Acta Obstet Gynecol Scand Original Research Articles INTRODUCTION: Sensitivity and specificity of colposcopy vary greatly between studies and efficacy in clinical studies seldom corresponds with effectiveness in a real‐life setting. It is unclear whether colposcopists’ experience affects assessment; studies show divergent results. The study's objective was to investigate the accuracy of colposcopies in the Swedish screening program, the variability in colposcopists’ assessments and whether degree of experience affects accuracy in a routine setting. MATERIAL AND METHODS: Cross‐sectional register study. All colposcopic assessments with a concomitant histopathological sample from women aged at least 18 years, performed between 1999 and September 2020 in Sweden. The main outcome measure was accuracy. The accuracy of colposcopic assessments was calculated as overall agreement with linked biopsies, with three outcomes: Normal vs Atypical, Normal vs Low‐Grade Atypical vs High‐Grade Atypical, and Non‐High‐Grade Atypical vs High‐Grade Atypical. A time‐trend analysis was performed. The accuracy of identifiable colposcopists related to experience was analyzed. RESULTS: In total, 82 289 colposcopic assessments with linked biopsies were included for analysis of the outcome Normal vs Atypical; average accuracy was 63%. Overrating colposcopic findings was four times more common than underrating. No time trend in accuracy was noted during the study period. Accuracy in distinguishing High‐Grade from Non‐High‐Grade lesions was better: 76%. Among identifiable colposcopists, overall accuracy was 67%. Some had significantly better accuracy than others, but no correlation with experience was found. CONCLUSIONS: Colposcopy, including in a referral setting, has low accuracy in distinguishing Normal from Atypical. Increased experience alone does not lead to improvement. This is supported by the substantial differences in performance between colposcopists. John Wiley and Sons Inc. 2023-03-06 /pmc/articles/PMC10072243/ /pubmed/36879505 http://dx.doi.org/10.1111/aogs.14538 Text en © 2023 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG). https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research Articles
Alfonzo, Emilia
Zhang, Chenyang
Daneshpip, Forogh
Strander, Björn
Accuracy of colposcopy in the Swedish screening program
title Accuracy of colposcopy in the Swedish screening program
title_full Accuracy of colposcopy in the Swedish screening program
title_fullStr Accuracy of colposcopy in the Swedish screening program
title_full_unstemmed Accuracy of colposcopy in the Swedish screening program
title_short Accuracy of colposcopy in the Swedish screening program
title_sort accuracy of colposcopy in the swedish screening program
topic Original Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10072243/
https://www.ncbi.nlm.nih.gov/pubmed/36879505
http://dx.doi.org/10.1111/aogs.14538
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