ClC-7 drives intraphagosomal chloride accumulation to support hydrolase activity and phagosome resolution

Degradative organelles contain enzymes that function optimally at the acidic pH generated by the V-ATPase. The resulting transmembrane H(+) gradient also energizes the secondary transport of several solutes, including Cl(−). We report that Cl(−) influx, driven by the 2Cl(−)/H(+) exchanger ClC-7, is...

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Detalles Bibliográficos
Autores principales: Wu, Jing Ze, Zeziulia, Mariia, Kwon, Whijin, Jentsch, Thomas J., Grinstein, Sergio, Freeman, Spencer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10072274/
https://www.ncbi.nlm.nih.gov/pubmed/37010469
http://dx.doi.org/10.1083/jcb.202208155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10072274/
https://www.ncbi.nlm.nih.gov/pubmed/37010469
http://dx.doi.org/10.1083/jcb.202208155

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