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ClC-7 drives intraphagosomal chloride accumulation to support hydrolase activity and phagosome resolution
Degradative organelles contain enzymes that function optimally at the acidic pH generated by the V-ATPase. The resulting transmembrane H(+) gradient also energizes the secondary transport of several solutes, including Cl(−). We report that Cl(−) influx, driven by the 2Cl(−)/H(+) exchanger ClC-7, is...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10072274/ https://www.ncbi.nlm.nih.gov/pubmed/37010469 http://dx.doi.org/10.1083/jcb.202208155 |