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The potential of dynamic (99m)Tc-sestamibi cadmium zinc telluride-single-photon emission computed tomography camera assessing myocardial flow reserve in patients with heart failure with preserved ejection fraction

AIMS: Coronary microvascular dysfunction (CMD) is related to the pathophysiology, mortality, and morbidity of heart failure with preserved ejection fraction (HFpEF). A novel single-photon emission computed tomography (SPECT) camera with cadmium zinc telluride (CZT) detectors allows for the quantific...

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Autores principales: Yoshida, Satoya, Unno, Kazumasa, Nanasato, Mamoru, Niimi, Takanaga, Inukai, Kohei, Morisaki, Hidenori, Hattori, Tomoki, Hirose, Miku, Hayashi, Takumi, Uchida, Noriya, Simoda, Masahiro, Oishi, Hideo, Ando, Monami, Hirayama, Kenshi, Takenaka, Masaki, Maeda, Mayuho, Yoshida, Ruka, Ogura, Yasuhiro, Suzuki, Hirohiko, Furusawa, Kenji, Morimoto, Ryota, Kato, Katsuhiko, Isobe, Satoshi, Yoshida, Yukihiko, Murohara, Toyoaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10072870/
https://www.ncbi.nlm.nih.gov/pubmed/37026023
http://dx.doi.org/10.1093/ehjopen/oead028
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author Yoshida, Satoya
Unno, Kazumasa
Nanasato, Mamoru
Niimi, Takanaga
Inukai, Kohei
Morisaki, Hidenori
Hattori, Tomoki
Hirose, Miku
Hayashi, Takumi
Uchida, Noriya
Simoda, Masahiro
Oishi, Hideo
Ando, Monami
Hirayama, Kenshi
Takenaka, Masaki
Maeda, Mayuho
Yoshida, Ruka
Ogura, Yasuhiro
Suzuki, Hirohiko
Furusawa, Kenji
Morimoto, Ryota
Kato, Katsuhiko
Isobe, Satoshi
Yoshida, Yukihiko
Murohara, Toyoaki
author_facet Yoshida, Satoya
Unno, Kazumasa
Nanasato, Mamoru
Niimi, Takanaga
Inukai, Kohei
Morisaki, Hidenori
Hattori, Tomoki
Hirose, Miku
Hayashi, Takumi
Uchida, Noriya
Simoda, Masahiro
Oishi, Hideo
Ando, Monami
Hirayama, Kenshi
Takenaka, Masaki
Maeda, Mayuho
Yoshida, Ruka
Ogura, Yasuhiro
Suzuki, Hirohiko
Furusawa, Kenji
Morimoto, Ryota
Kato, Katsuhiko
Isobe, Satoshi
Yoshida, Yukihiko
Murohara, Toyoaki
author_sort Yoshida, Satoya
collection PubMed
description AIMS: Coronary microvascular dysfunction (CMD) is related to the pathophysiology, mortality, and morbidity of heart failure with preserved ejection fraction (HFpEF). A novel single-photon emission computed tomography (SPECT) camera with cadmium zinc telluride (CZT) detectors allows for the quantification of absolute myocardial blood flow and myocardial flow reserve (MFR) in patients with coronary artery disease. However, the potential of CZT-SPECT assessing for CMD has never been evaluated in patients with HFpEF. METHODS AND RESULTS: The clinical records of 127 consecutive patients who underwent dynamic CZT-SPECT were retrospectively reviewed. Rest and stress scanning were started simultaneously with 3 and 9 MBq/kg of (99)mTc-sestamibi administration, respectively. Dynamic CZT-SPECT imaging data were analysed using a net-retention model with commercially available software. Transthoracic echocardiography was performed in all patients. The MFR value was significantly lower in the HFpEF group (mean ± SEM = 2.00 ± 0.097) than that in the non-HFpEF group (mean ± SEM = 2.74 ± 0.14, P = 0.0004). A receiver operating characteristic analysis indicated that if a cut-off value of 2.525 was applied, MFR could efficiently distinguish HFpEF from non-HFpEF. Heart failure with preserved ejection fraction had a consistently low MFR, regardless of the diastolic dysfunction score. Heart failure with preserved ejection fraction patients with MFR values lower than 2.075 had a significantly higher incidence of heart failure exacerbation. CONCLUSION: Myocardial flow reserve assessed by CZT-SPECT was significantly reduced in patients with HFpEF. A lower MFR was associated with a higher hospitalization rate in these patients. Myocardial flow reserve assessed by CZT-SPECT has the potential to predict future adverse events and stratify the severity of disease in patients with HFpEF.
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spelling pubmed-100728702023-04-05 The potential of dynamic (99m)Tc-sestamibi cadmium zinc telluride-single-photon emission computed tomography camera assessing myocardial flow reserve in patients with heart failure with preserved ejection fraction Yoshida, Satoya Unno, Kazumasa Nanasato, Mamoru Niimi, Takanaga Inukai, Kohei Morisaki, Hidenori Hattori, Tomoki Hirose, Miku Hayashi, Takumi Uchida, Noriya Simoda, Masahiro Oishi, Hideo Ando, Monami Hirayama, Kenshi Takenaka, Masaki Maeda, Mayuho Yoshida, Ruka Ogura, Yasuhiro Suzuki, Hirohiko Furusawa, Kenji Morimoto, Ryota Kato, Katsuhiko Isobe, Satoshi Yoshida, Yukihiko Murohara, Toyoaki Eur Heart J Open Original Article AIMS: Coronary microvascular dysfunction (CMD) is related to the pathophysiology, mortality, and morbidity of heart failure with preserved ejection fraction (HFpEF). A novel single-photon emission computed tomography (SPECT) camera with cadmium zinc telluride (CZT) detectors allows for the quantification of absolute myocardial blood flow and myocardial flow reserve (MFR) in patients with coronary artery disease. However, the potential of CZT-SPECT assessing for CMD has never been evaluated in patients with HFpEF. METHODS AND RESULTS: The clinical records of 127 consecutive patients who underwent dynamic CZT-SPECT were retrospectively reviewed. Rest and stress scanning were started simultaneously with 3 and 9 MBq/kg of (99)mTc-sestamibi administration, respectively. Dynamic CZT-SPECT imaging data were analysed using a net-retention model with commercially available software. Transthoracic echocardiography was performed in all patients. The MFR value was significantly lower in the HFpEF group (mean ± SEM = 2.00 ± 0.097) than that in the non-HFpEF group (mean ± SEM = 2.74 ± 0.14, P = 0.0004). A receiver operating characteristic analysis indicated that if a cut-off value of 2.525 was applied, MFR could efficiently distinguish HFpEF from non-HFpEF. Heart failure with preserved ejection fraction had a consistently low MFR, regardless of the diastolic dysfunction score. Heart failure with preserved ejection fraction patients with MFR values lower than 2.075 had a significantly higher incidence of heart failure exacerbation. CONCLUSION: Myocardial flow reserve assessed by CZT-SPECT was significantly reduced in patients with HFpEF. A lower MFR was associated with a higher hospitalization rate in these patients. Myocardial flow reserve assessed by CZT-SPECT has the potential to predict future adverse events and stratify the severity of disease in patients with HFpEF. Oxford University Press 2023-03-14 /pmc/articles/PMC10072870/ /pubmed/37026023 http://dx.doi.org/10.1093/ehjopen/oead028 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Article
Yoshida, Satoya
Unno, Kazumasa
Nanasato, Mamoru
Niimi, Takanaga
Inukai, Kohei
Morisaki, Hidenori
Hattori, Tomoki
Hirose, Miku
Hayashi, Takumi
Uchida, Noriya
Simoda, Masahiro
Oishi, Hideo
Ando, Monami
Hirayama, Kenshi
Takenaka, Masaki
Maeda, Mayuho
Yoshida, Ruka
Ogura, Yasuhiro
Suzuki, Hirohiko
Furusawa, Kenji
Morimoto, Ryota
Kato, Katsuhiko
Isobe, Satoshi
Yoshida, Yukihiko
Murohara, Toyoaki
The potential of dynamic (99m)Tc-sestamibi cadmium zinc telluride-single-photon emission computed tomography camera assessing myocardial flow reserve in patients with heart failure with preserved ejection fraction
title The potential of dynamic (99m)Tc-sestamibi cadmium zinc telluride-single-photon emission computed tomography camera assessing myocardial flow reserve in patients with heart failure with preserved ejection fraction
title_full The potential of dynamic (99m)Tc-sestamibi cadmium zinc telluride-single-photon emission computed tomography camera assessing myocardial flow reserve in patients with heart failure with preserved ejection fraction
title_fullStr The potential of dynamic (99m)Tc-sestamibi cadmium zinc telluride-single-photon emission computed tomography camera assessing myocardial flow reserve in patients with heart failure with preserved ejection fraction
title_full_unstemmed The potential of dynamic (99m)Tc-sestamibi cadmium zinc telluride-single-photon emission computed tomography camera assessing myocardial flow reserve in patients with heart failure with preserved ejection fraction
title_short The potential of dynamic (99m)Tc-sestamibi cadmium zinc telluride-single-photon emission computed tomography camera assessing myocardial flow reserve in patients with heart failure with preserved ejection fraction
title_sort potential of dynamic (99m)tc-sestamibi cadmium zinc telluride-single-photon emission computed tomography camera assessing myocardial flow reserve in patients with heart failure with preserved ejection fraction
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10072870/
https://www.ncbi.nlm.nih.gov/pubmed/37026023
http://dx.doi.org/10.1093/ehjopen/oead028
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