The multi-tissue landscape of somatic mtDNA mutations indicates tissue-specific accumulation and removal in aging

Accumulation of somatic mutations in the mitochondrial genome (mtDNA) has long been proposed as a possible mechanism of mitochondrial and tissue dysfunction that occurs during aging. A thorough characterization of age-associated mtDNA somatic mutations has been hampered by the limited ability to det...

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Detalles Bibliográficos
Autores principales: Sanchez-Contreras, Monica, Sweetwyne, Mariya T, Tsantilas, Kristine A, Whitson, Jeremy A, Campbell, Matthew D, Kohrn, Brenden F, Kim, Hyeon Jeong, Hipp, Michael J, Fredrickson, Jeanne, Nguyen, Megan M, Hurley, James B, Marcinek, David J, Rabinovitch, Peter S, Kennedy, Scott R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10072880/
https://www.ncbi.nlm.nih.gov/pubmed/36799304
http://dx.doi.org/10.7554/eLife.83395

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