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Primary Squamous Cell Carcinoma of Gallbladder With Hepatic Invasion

Squamous cell carcinoma of the gallbladder is a profoundly rare tumor. It is one of the most aggressive and deadly forms of gallbladder cancer, often being diagnosed at a later stage. There are no definitive risk factors described for this specific type of gallbladder tumor when compared to other fo...

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Autores principales: Willson, Conner M, Barsoum, Nathalie, Khan, Mustafa Tamim Alam, Rushton, Jennifer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10072881/
https://www.ncbi.nlm.nih.gov/pubmed/37025738
http://dx.doi.org/10.7759/cureus.35795
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author Willson, Conner M
Barsoum, Nathalie
Khan, Mustafa Tamim Alam
Rushton, Jennifer
author_facet Willson, Conner M
Barsoum, Nathalie
Khan, Mustafa Tamim Alam
Rushton, Jennifer
author_sort Willson, Conner M
collection PubMed
description Squamous cell carcinoma of the gallbladder is a profoundly rare tumor. It is one of the most aggressive and deadly forms of gallbladder cancer, often being diagnosed at a later stage. There are no definitive risk factors described for this specific type of gallbladder tumor when compared to other forms of gallbladder carcinoma. This case is regarding a 64-year-old female who was found to have primary squamous cell carcinoma of the gallbladder during an attempted cholecystectomy. Her tumor was found to have invaded her liver. The tumor displayed characteristic qualities of a pure squamous cell carcinoma and was positive for CK7 and p63 upon pathological analysis. Best results for treatment for this condition are achieved via R0 resection. Adjuvant therapy with chemoradiation has not been well-defined nor very effective in prior cases.
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spelling pubmed-100728812023-04-05 Primary Squamous Cell Carcinoma of Gallbladder With Hepatic Invasion Willson, Conner M Barsoum, Nathalie Khan, Mustafa Tamim Alam Rushton, Jennifer Cureus Pathology Squamous cell carcinoma of the gallbladder is a profoundly rare tumor. It is one of the most aggressive and deadly forms of gallbladder cancer, often being diagnosed at a later stage. There are no definitive risk factors described for this specific type of gallbladder tumor when compared to other forms of gallbladder carcinoma. This case is regarding a 64-year-old female who was found to have primary squamous cell carcinoma of the gallbladder during an attempted cholecystectomy. Her tumor was found to have invaded her liver. The tumor displayed characteristic qualities of a pure squamous cell carcinoma and was positive for CK7 and p63 upon pathological analysis. Best results for treatment for this condition are achieved via R0 resection. Adjuvant therapy with chemoradiation has not been well-defined nor very effective in prior cases. Cureus 2023-03-05 /pmc/articles/PMC10072881/ /pubmed/37025738 http://dx.doi.org/10.7759/cureus.35795 Text en Copyright © 2023, Willson et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pathology
Willson, Conner M
Barsoum, Nathalie
Khan, Mustafa Tamim Alam
Rushton, Jennifer
Primary Squamous Cell Carcinoma of Gallbladder With Hepatic Invasion
title Primary Squamous Cell Carcinoma of Gallbladder With Hepatic Invasion
title_full Primary Squamous Cell Carcinoma of Gallbladder With Hepatic Invasion
title_fullStr Primary Squamous Cell Carcinoma of Gallbladder With Hepatic Invasion
title_full_unstemmed Primary Squamous Cell Carcinoma of Gallbladder With Hepatic Invasion
title_short Primary Squamous Cell Carcinoma of Gallbladder With Hepatic Invasion
title_sort primary squamous cell carcinoma of gallbladder with hepatic invasion
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10072881/
https://www.ncbi.nlm.nih.gov/pubmed/37025738
http://dx.doi.org/10.7759/cureus.35795
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