Enhanced fitness of SARS-CoV-2 B.1.617.2 Delta variant in ferrets

Competition assays were conducted in vitro and in vivo to examine how the Delta (B.1.617.2) variant displaced the prototype Washington/1/2020 (WA/1) strain. While WA/1 virus exhibited a moderately increased proportion compared to that in the inoculum following co-infection in human respiratory cells...

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Detalles Bibliográficos
Autores principales: Sun, Xiangjie, Belser, Jessica A., Kieran, Troy J., Brock, Nicole, Pulit-Penaloza, Joanna A., Pappas, Claudia, Basu Thakur, Poulami, Jones, Joyce, Wentworth, David E., Zhou, Bin, Tumpey, Terrence M., Maines, Taronna R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073010/
https://www.ncbi.nlm.nih.gov/pubmed/37028126
http://dx.doi.org/10.1016/j.virol.2023.03.014
Descripción
Sumario:Competition assays were conducted in vitro and in vivo to examine how the Delta (B.1.617.2) variant displaced the prototype Washington/1/2020 (WA/1) strain. While WA/1 virus exhibited a moderately increased proportion compared to that in the inoculum following co-infection in human respiratory cells, Delta variant possessed a substantial in vivo fitness advantage as this virus becoming predominant in both inoculated and contact animals. This work identifies critical traits of the Delta variant that likely played a role in it becoming a dominant variant and highlights the necessities of employing multiple model systems to assess the fitness of newly emerged SARS-CoV-2 variants.

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