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Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson’s disease
Elevated urine bis(monoacylglycerol)phosphate (BMP) levels have been found in gain-of-kinase function LRRK2 G2019S mutation carriers. Here, we have expanded urine BMP analysis to other Parkinson’s disease (PD) associated mutations and found them to be consistently elevated in carriers of LRRK2 G2019...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073226/ https://www.ncbi.nlm.nih.gov/pubmed/37015928 http://dx.doi.org/10.1038/s41531-023-00482-4 |
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| author | Gomes, Sara Garrido, Alicia Tonelli, Francesca Obiang, Donina Tolosa, Eduardo Martí, Maria José Ruiz-Martínez, Javier Vinagre-Aragón, Ana Hernandez-Eguiazu, Haizea Croitoru, Ioana Marshall, Vicky L. Koenig, Theresa Hotzy, Christoph Hsieh, Frank Sakalosh, Marianna Tengstrand, Elizabeth Padmanabhan, Shalini Merchant, Kalpana Bruecke, Christof Pirker, Walter Zimprich, Alexander Sammler, Esther |
| author_facet | Gomes, Sara Garrido, Alicia Tonelli, Francesca Obiang, Donina Tolosa, Eduardo Martí, Maria José Ruiz-Martínez, Javier Vinagre-Aragón, Ana Hernandez-Eguiazu, Haizea Croitoru, Ioana Marshall, Vicky L. Koenig, Theresa Hotzy, Christoph Hsieh, Frank Sakalosh, Marianna Tengstrand, Elizabeth Padmanabhan, Shalini Merchant, Kalpana Bruecke, Christof Pirker, Walter Zimprich, Alexander Sammler, Esther |
| author_sort | Gomes, Sara |
| collection | PubMed |
| description | Elevated urine bis(monoacylglycerol)phosphate (BMP) levels have been found in gain-of-kinase function LRRK2 G2019S mutation carriers. Here, we have expanded urine BMP analysis to other Parkinson’s disease (PD) associated mutations and found them to be consistently elevated in carriers of LRRK2 G2019S and R1441G/C as well as VPS35 D620N mutations. Urine BMP levels are promising biomarkers for patient stratification and potentially target engagement in clinical trials of emerging targeted PD therapies. |
| format | Online Article Text |
| id | pubmed-10073226 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-100732262023-04-06 Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson’s disease Gomes, Sara Garrido, Alicia Tonelli, Francesca Obiang, Donina Tolosa, Eduardo Martí, Maria José Ruiz-Martínez, Javier Vinagre-Aragón, Ana Hernandez-Eguiazu, Haizea Croitoru, Ioana Marshall, Vicky L. Koenig, Theresa Hotzy, Christoph Hsieh, Frank Sakalosh, Marianna Tengstrand, Elizabeth Padmanabhan, Shalini Merchant, Kalpana Bruecke, Christof Pirker, Walter Zimprich, Alexander Sammler, Esther NPJ Parkinsons Dis Brief Communication Elevated urine bis(monoacylglycerol)phosphate (BMP) levels have been found in gain-of-kinase function LRRK2 G2019S mutation carriers. Here, we have expanded urine BMP analysis to other Parkinson’s disease (PD) associated mutations and found them to be consistently elevated in carriers of LRRK2 G2019S and R1441G/C as well as VPS35 D620N mutations. Urine BMP levels are promising biomarkers for patient stratification and potentially target engagement in clinical trials of emerging targeted PD therapies. Nature Publishing Group UK 2023-04-04 /pmc/articles/PMC10073226/ /pubmed/37015928 http://dx.doi.org/10.1038/s41531-023-00482-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Brief Communication Gomes, Sara Garrido, Alicia Tonelli, Francesca Obiang, Donina Tolosa, Eduardo Martí, Maria José Ruiz-Martínez, Javier Vinagre-Aragón, Ana Hernandez-Eguiazu, Haizea Croitoru, Ioana Marshall, Vicky L. Koenig, Theresa Hotzy, Christoph Hsieh, Frank Sakalosh, Marianna Tengstrand, Elizabeth Padmanabhan, Shalini Merchant, Kalpana Bruecke, Christof Pirker, Walter Zimprich, Alexander Sammler, Esther Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson’s disease |
| title | Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson’s disease |
| title_full | Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson’s disease |
| title_fullStr | Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson’s disease |
| title_full_unstemmed | Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson’s disease |
| title_short | Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson’s disease |
| title_sort | elevated urine bmp phospholipids in lrrk2 and vps35 mutation carriers with and without parkinson’s disease |
| topic | Brief Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073226/ https://www.ncbi.nlm.nih.gov/pubmed/37015928 http://dx.doi.org/10.1038/s41531-023-00482-4 |
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