Discovery of IHMT-MST1-39 as a novel MST1 kinase inhibitor and AMPK activator for the treatment of diabetes mellitus

Insulin-producing pancreatic β cell death is the fundamental cause of type 1 diabetes (T1D) and a contributing factor to type 2 diabetes (T2D). Moreover, metabolic disorder is another hallmark of T2D. Mammalian sterile 20-like kinase 1 (MST1) contributes to the progression of diabetes mellitus throu...

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Detalles Bibliográficos
Autores principales: Wang, Junjie, Qi, Ziping, Wu, Yun, Wang, Aoli, Liu, Qingwang, Zou, Fengming, Wang, Beilei, Qi, Shuang, Cao, Jiangyan, Hu, Chen, Shi, Chenliang, Liang, Qianmao, Wang, Li, Liu, Jing, Wang, Wenchao, Liu, Qingsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073293/
https://www.ncbi.nlm.nih.gov/pubmed/37015918
http://dx.doi.org/10.1038/s41392-023-01352-4

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