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The role of β-catenin in cardiac diseases
The Wnt/β-catenin signaling pathway is a classical Wnt pathway that regulates the stability and nuclear localization of β-catenin and plays an important role in adult heart development and cardiac tissue homeostasis. In recent years, an increasing number of researchers have implicated the dysregulat...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073558/ https://www.ncbi.nlm.nih.gov/pubmed/37033656 http://dx.doi.org/10.3389/fphar.2023.1157043 |
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author | Ni, Beibei Sun, Meijuan Zhao, Jun Wang, Jiao Cao, Zhanqi |
author_facet | Ni, Beibei Sun, Meijuan Zhao, Jun Wang, Jiao Cao, Zhanqi |
author_sort | Ni, Beibei |
collection | PubMed |
description | The Wnt/β-catenin signaling pathway is a classical Wnt pathway that regulates the stability and nuclear localization of β-catenin and plays an important role in adult heart development and cardiac tissue homeostasis. In recent years, an increasing number of researchers have implicated the dysregulation of this signaling pathway in a variety of cardiac diseases, such as myocardial infarction, arrhythmias, arrhythmogenic cardiomyopathy, diabetic cardiomyopathies, and myocardial hypertrophy. The morbidity and mortality of cardiac diseases are increasing, which brings great challenges to clinical treatment and seriously affects patient health. Thus, understanding the biological roles of the Wnt/β-catenin pathway in these diseases may be essential for cardiac disease treatment and diagnosis to improve patient quality of life. In this review, we summarize current research on the roles of β-catenin in human cardiac diseases and potential inhibitors of Wnt/β-catenin, which may provide new strategies for cardiac disease therapies. |
format | Online Article Text |
id | pubmed-10073558 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100735582023-04-06 The role of β-catenin in cardiac diseases Ni, Beibei Sun, Meijuan Zhao, Jun Wang, Jiao Cao, Zhanqi Front Pharmacol Pharmacology The Wnt/β-catenin signaling pathway is a classical Wnt pathway that regulates the stability and nuclear localization of β-catenin and plays an important role in adult heart development and cardiac tissue homeostasis. In recent years, an increasing number of researchers have implicated the dysregulation of this signaling pathway in a variety of cardiac diseases, such as myocardial infarction, arrhythmias, arrhythmogenic cardiomyopathy, diabetic cardiomyopathies, and myocardial hypertrophy. The morbidity and mortality of cardiac diseases are increasing, which brings great challenges to clinical treatment and seriously affects patient health. Thus, understanding the biological roles of the Wnt/β-catenin pathway in these diseases may be essential for cardiac disease treatment and diagnosis to improve patient quality of life. In this review, we summarize current research on the roles of β-catenin in human cardiac diseases and potential inhibitors of Wnt/β-catenin, which may provide new strategies for cardiac disease therapies. Frontiers Media S.A. 2023-03-22 /pmc/articles/PMC10073558/ /pubmed/37033656 http://dx.doi.org/10.3389/fphar.2023.1157043 Text en Copyright © 2023 Ni, Sun, Zhao, Wang and Cao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Ni, Beibei Sun, Meijuan Zhao, Jun Wang, Jiao Cao, Zhanqi The role of β-catenin in cardiac diseases |
title | The role of β-catenin in cardiac diseases |
title_full | The role of β-catenin in cardiac diseases |
title_fullStr | The role of β-catenin in cardiac diseases |
title_full_unstemmed | The role of β-catenin in cardiac diseases |
title_short | The role of β-catenin in cardiac diseases |
title_sort | role of β-catenin in cardiac diseases |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073558/ https://www.ncbi.nlm.nih.gov/pubmed/37033656 http://dx.doi.org/10.3389/fphar.2023.1157043 |
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