Cargando…

The role of β-catenin in cardiac diseases

The Wnt/β-catenin signaling pathway is a classical Wnt pathway that regulates the stability and nuclear localization of β-catenin and plays an important role in adult heart development and cardiac tissue homeostasis. In recent years, an increasing number of researchers have implicated the dysregulat...

Descripción completa

Detalles Bibliográficos
Autores principales: Ni, Beibei, Sun, Meijuan, Zhao, Jun, Wang, Jiao, Cao, Zhanqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073558/
https://www.ncbi.nlm.nih.gov/pubmed/37033656
http://dx.doi.org/10.3389/fphar.2023.1157043
_version_ 1785019595576311808
author Ni, Beibei
Sun, Meijuan
Zhao, Jun
Wang, Jiao
Cao, Zhanqi
author_facet Ni, Beibei
Sun, Meijuan
Zhao, Jun
Wang, Jiao
Cao, Zhanqi
author_sort Ni, Beibei
collection PubMed
description The Wnt/β-catenin signaling pathway is a classical Wnt pathway that regulates the stability and nuclear localization of β-catenin and plays an important role in adult heart development and cardiac tissue homeostasis. In recent years, an increasing number of researchers have implicated the dysregulation of this signaling pathway in a variety of cardiac diseases, such as myocardial infarction, arrhythmias, arrhythmogenic cardiomyopathy, diabetic cardiomyopathies, and myocardial hypertrophy. The morbidity and mortality of cardiac diseases are increasing, which brings great challenges to clinical treatment and seriously affects patient health. Thus, understanding the biological roles of the Wnt/β-catenin pathway in these diseases may be essential for cardiac disease treatment and diagnosis to improve patient quality of life. In this review, we summarize current research on the roles of β-catenin in human cardiac diseases and potential inhibitors of Wnt/β-catenin, which may provide new strategies for cardiac disease therapies.
format Online
Article
Text
id pubmed-10073558
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-100735582023-04-06 The role of β-catenin in cardiac diseases Ni, Beibei Sun, Meijuan Zhao, Jun Wang, Jiao Cao, Zhanqi Front Pharmacol Pharmacology The Wnt/β-catenin signaling pathway is a classical Wnt pathway that regulates the stability and nuclear localization of β-catenin and plays an important role in adult heart development and cardiac tissue homeostasis. In recent years, an increasing number of researchers have implicated the dysregulation of this signaling pathway in a variety of cardiac diseases, such as myocardial infarction, arrhythmias, arrhythmogenic cardiomyopathy, diabetic cardiomyopathies, and myocardial hypertrophy. The morbidity and mortality of cardiac diseases are increasing, which brings great challenges to clinical treatment and seriously affects patient health. Thus, understanding the biological roles of the Wnt/β-catenin pathway in these diseases may be essential for cardiac disease treatment and diagnosis to improve patient quality of life. In this review, we summarize current research on the roles of β-catenin in human cardiac diseases and potential inhibitors of Wnt/β-catenin, which may provide new strategies for cardiac disease therapies. Frontiers Media S.A. 2023-03-22 /pmc/articles/PMC10073558/ /pubmed/37033656 http://dx.doi.org/10.3389/fphar.2023.1157043 Text en Copyright © 2023 Ni, Sun, Zhao, Wang and Cao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Ni, Beibei
Sun, Meijuan
Zhao, Jun
Wang, Jiao
Cao, Zhanqi
The role of β-catenin in cardiac diseases
title The role of β-catenin in cardiac diseases
title_full The role of β-catenin in cardiac diseases
title_fullStr The role of β-catenin in cardiac diseases
title_full_unstemmed The role of β-catenin in cardiac diseases
title_short The role of β-catenin in cardiac diseases
title_sort role of β-catenin in cardiac diseases
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073558/
https://www.ncbi.nlm.nih.gov/pubmed/37033656
http://dx.doi.org/10.3389/fphar.2023.1157043
work_keys_str_mv AT nibeibei theroleofbcateninincardiacdiseases
AT sunmeijuan theroleofbcateninincardiacdiseases
AT zhaojun theroleofbcateninincardiacdiseases
AT wangjiao theroleofbcateninincardiacdiseases
AT caozhanqi theroleofbcateninincardiacdiseases
AT nibeibei roleofbcateninincardiacdiseases
AT sunmeijuan roleofbcateninincardiacdiseases
AT zhaojun roleofbcateninincardiacdiseases
AT wangjiao roleofbcateninincardiacdiseases
AT caozhanqi roleofbcateninincardiacdiseases