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Multi-transcriptomics reveals RLMF axis-mediated signaling molecules associated with bovine feed efficiency

The regulatory axis plays a vital role in interpreting the information exchange and interactions among mammal organs. In this study on feed efficiency, it was hypothesized that a rumen-liver-muscle-fat (RLMF) regulatory axis exists and scrutinized the flow of energy along the RLMF axis employing con...

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Autores principales: Yang, Chaoyun, Ding, Yanling, Dan, Xingang, Shi, Yuangang, Kang, Xiaolong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073569/
https://www.ncbi.nlm.nih.gov/pubmed/37035824
http://dx.doi.org/10.3389/fvets.2023.1090517
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author Yang, Chaoyun
Ding, Yanling
Dan, Xingang
Shi, Yuangang
Kang, Xiaolong
author_facet Yang, Chaoyun
Ding, Yanling
Dan, Xingang
Shi, Yuangang
Kang, Xiaolong
author_sort Yang, Chaoyun
collection PubMed
description The regulatory axis plays a vital role in interpreting the information exchange and interactions among mammal organs. In this study on feed efficiency, it was hypothesized that a rumen-liver-muscle-fat (RLMF) regulatory axis exists and scrutinized the flow of energy along the RLMF axis employing consensus network analysis from a spatial transcriptomic standpoint. Based on enrichment analysis and protein-protein interaction analysis of the consensus network and tissue-specific genes, it was discovered that carbohydrate metabolism, energy metabolism, immune and inflammatory responses were likely to be the biological processes that contribute most to feed efficiency variation on the RLMF regulatory axis. In addition, clusters of genes related to the electron respiratory chain, including ND (2,3,4,4L,5,6), NDUF (A13, A7, S6, B3, B6), COX (1,3), CYTB, UQCR11, ATP (6,8), clusters of genes related to fatty acid metabolism including APO (A1, A2, A4, B, C3), ALB, FG (A, G), as well as clusters of the ribosomal-related gene including RPL (8,18A,18,15,13, P1), the RPS (23,27A,3A,4X), and the PSM (A1-A7, B6, C1, C3, D2-D4, D8 D9, E1) could be the primary effector genes responsible for feed efficiency variation. The findings demonstrate that high feed efficiency cattle, through the synergistic action of the regulatory axis RLMF, may improve the efficiency of biological processes (carbohydrate metabolism, protein ubiquitination, and energy metabolism). Meanwhile, high feed efficiency cattle might enhance the ability to respond to immunity and inflammation, allowing nutrients to be efficiently distributed across these organs associated with digestion and absorption, energy-producing, and energy-storing organs. Elucidating the distribution of nutrients on the RLMF regulatory axis could facilitate an understanding of feed efficiency variation and achieve the study on its molecular regulation.
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spelling pubmed-100735692023-04-06 Multi-transcriptomics reveals RLMF axis-mediated signaling molecules associated with bovine feed efficiency Yang, Chaoyun Ding, Yanling Dan, Xingang Shi, Yuangang Kang, Xiaolong Front Vet Sci Veterinary Science The regulatory axis plays a vital role in interpreting the information exchange and interactions among mammal organs. In this study on feed efficiency, it was hypothesized that a rumen-liver-muscle-fat (RLMF) regulatory axis exists and scrutinized the flow of energy along the RLMF axis employing consensus network analysis from a spatial transcriptomic standpoint. Based on enrichment analysis and protein-protein interaction analysis of the consensus network and tissue-specific genes, it was discovered that carbohydrate metabolism, energy metabolism, immune and inflammatory responses were likely to be the biological processes that contribute most to feed efficiency variation on the RLMF regulatory axis. In addition, clusters of genes related to the electron respiratory chain, including ND (2,3,4,4L,5,6), NDUF (A13, A7, S6, B3, B6), COX (1,3), CYTB, UQCR11, ATP (6,8), clusters of genes related to fatty acid metabolism including APO (A1, A2, A4, B, C3), ALB, FG (A, G), as well as clusters of the ribosomal-related gene including RPL (8,18A,18,15,13, P1), the RPS (23,27A,3A,4X), and the PSM (A1-A7, B6, C1, C3, D2-D4, D8 D9, E1) could be the primary effector genes responsible for feed efficiency variation. The findings demonstrate that high feed efficiency cattle, through the synergistic action of the regulatory axis RLMF, may improve the efficiency of biological processes (carbohydrate metabolism, protein ubiquitination, and energy metabolism). Meanwhile, high feed efficiency cattle might enhance the ability to respond to immunity and inflammation, allowing nutrients to be efficiently distributed across these organs associated with digestion and absorption, energy-producing, and energy-storing organs. Elucidating the distribution of nutrients on the RLMF regulatory axis could facilitate an understanding of feed efficiency variation and achieve the study on its molecular regulation. Frontiers Media S.A. 2023-03-22 /pmc/articles/PMC10073569/ /pubmed/37035824 http://dx.doi.org/10.3389/fvets.2023.1090517 Text en Copyright © 2023 Yang, Ding, Dan, Shi and Kang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Yang, Chaoyun
Ding, Yanling
Dan, Xingang
Shi, Yuangang
Kang, Xiaolong
Multi-transcriptomics reveals RLMF axis-mediated signaling molecules associated with bovine feed efficiency
title Multi-transcriptomics reveals RLMF axis-mediated signaling molecules associated with bovine feed efficiency
title_full Multi-transcriptomics reveals RLMF axis-mediated signaling molecules associated with bovine feed efficiency
title_fullStr Multi-transcriptomics reveals RLMF axis-mediated signaling molecules associated with bovine feed efficiency
title_full_unstemmed Multi-transcriptomics reveals RLMF axis-mediated signaling molecules associated with bovine feed efficiency
title_short Multi-transcriptomics reveals RLMF axis-mediated signaling molecules associated with bovine feed efficiency
title_sort multi-transcriptomics reveals rlmf axis-mediated signaling molecules associated with bovine feed efficiency
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073569/
https://www.ncbi.nlm.nih.gov/pubmed/37035824
http://dx.doi.org/10.3389/fvets.2023.1090517
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