Sulfated polysaccharides act as baits to interfere with the binding of the spike protein (SARS-CoV-2) to the ACE2 receptor and can be administered through food

Human civilization is experiencing a global crisis involving an unprecedented viral pandemic, with a high mortality rate, uncontrolled spread, and few effective drugs for treatment. Here, we critically evaluate how sulfated polysaccharides can be applied via foods to reduce the infectious process an...

Descripción completa

Detalles Bibliográficos
Autores principales: Barbosa, Jhonatas Rodrigues, de Fátima Henriques Lourenço, Lúcia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd. 2023
Materias:
Opinions and Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073580/
https://www.ncbi.nlm.nih.gov/pubmed/37035109
http://dx.doi.org/10.1016/j.jff.2023.105532
_version_ 1785019602458116096
author Barbosa, Jhonatas Rodrigues
de Fátima Henriques Lourenço, Lúcia
author_facet Barbosa, Jhonatas Rodrigues
de Fátima Henriques Lourenço, Lúcia
author_sort Barbosa, Jhonatas Rodrigues
collection PubMed
description Human civilization is experiencing a global crisis involving an unprecedented viral pandemic, with a high mortality rate, uncontrolled spread, and few effective drugs for treatment. Here, we critically evaluate how sulfated polysaccharides can be applied via foods to reduce the infectious process and increase the chances of an adequate immune response. The approach is directed to the infectious process by SARS-CoV-2 and protein S as a therapeutic focus. We discuss the antiviral activities of certain natural and specific sulfated polysaccharides that bind tightly to protein S. Finally, we identified that sulfated polysaccharides act as baits to interfere with the binding of the spike protein (SARS-CoV-2) to the ACE2 receptor and can be administered through food.
format Online
Article
Text
id pubmed-10073580
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher The Author(s). Published by Elsevier Ltd.
record_format MEDLINE/PubMed
spelling pubmed-100735802023-04-05 Sulfated polysaccharides act as baits to interfere with the binding of the spike protein (SARS-CoV-2) to the ACE2 receptor and can be administered through food Barbosa, Jhonatas Rodrigues de Fátima Henriques Lourenço, Lúcia J Funct Foods Opinions and Perspectives Human civilization is experiencing a global crisis involving an unprecedented viral pandemic, with a high mortality rate, uncontrolled spread, and few effective drugs for treatment. Here, we critically evaluate how sulfated polysaccharides can be applied via foods to reduce the infectious process and increase the chances of an adequate immune response. The approach is directed to the infectious process by SARS-CoV-2 and protein S as a therapeutic focus. We discuss the antiviral activities of certain natural and specific sulfated polysaccharides that bind tightly to protein S. Finally, we identified that sulfated polysaccharides act as baits to interfere with the binding of the spike protein (SARS-CoV-2) to the ACE2 receptor and can be administered through food. The Author(s). Published by Elsevier Ltd. 2023-05 2023-04-05 /pmc/articles/PMC10073580/ /pubmed/37035109 http://dx.doi.org/10.1016/j.jff.2023.105532 Text en © 2023 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Opinions and Perspectives
Barbosa, Jhonatas Rodrigues
de Fátima Henriques Lourenço, Lúcia
Sulfated polysaccharides act as baits to interfere with the binding of the spike protein (SARS-CoV-2) to the ACE2 receptor and can be administered through food
title Sulfated polysaccharides act as baits to interfere with the binding of the spike protein (SARS-CoV-2) to the ACE2 receptor and can be administered through food
title_full Sulfated polysaccharides act as baits to interfere with the binding of the spike protein (SARS-CoV-2) to the ACE2 receptor and can be administered through food
title_fullStr Sulfated polysaccharides act as baits to interfere with the binding of the spike protein (SARS-CoV-2) to the ACE2 receptor and can be administered through food
title_full_unstemmed Sulfated polysaccharides act as baits to interfere with the binding of the spike protein (SARS-CoV-2) to the ACE2 receptor and can be administered through food
title_short Sulfated polysaccharides act as baits to interfere with the binding of the spike protein (SARS-CoV-2) to the ACE2 receptor and can be administered through food
title_sort sulfated polysaccharides act as baits to interfere with the binding of the spike protein (sars-cov-2) to the ace2 receptor and can be administered through food
topic Opinions and Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073580/
https://www.ncbi.nlm.nih.gov/pubmed/37035109
http://dx.doi.org/10.1016/j.jff.2023.105532
work_keys_str_mv AT barbosajhonatasrodrigues sulfatedpolysaccharidesactasbaitstointerferewiththebindingofthespikeproteinsarscov2totheace2receptorandcanbeadministeredthroughfood
AT defatimahenriqueslourencolucia sulfatedpolysaccharidesactasbaitstointerferewiththebindingofthespikeproteinsarscov2totheace2receptorandcanbeadministeredthroughfood

Ejemplares similares