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Nitric oxide signaling in ctenophores
Nitric oxide (NO) is one of the most ancient and versatile signal molecules across all domains of life. NO signaling might also play an essential role in the origin of animal organization. Yet, practically nothing is known about the distribution and functions of NO-dependent signaling pathways in re...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073611/ https://www.ncbi.nlm.nih.gov/pubmed/37034176 http://dx.doi.org/10.3389/fnins.2023.1125433 |
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author | Moroz, Leonid L. Mukherjee, Krishanu Romanova, Daria Y. |
author_facet | Moroz, Leonid L. Mukherjee, Krishanu Romanova, Daria Y. |
author_sort | Moroz, Leonid L. |
collection | PubMed |
description | Nitric oxide (NO) is one of the most ancient and versatile signal molecules across all domains of life. NO signaling might also play an essential role in the origin of animal organization. Yet, practically nothing is known about the distribution and functions of NO-dependent signaling pathways in representatives of early branching metazoans such as Ctenophora. Here, we explore the presence and organization of NO signaling components using Mnemiopsis and kin as essential reference species. We show that NO synthase (NOS) is present in at least eight ctenophore species, including Euplokamis and Coeloplana, representing the most basal ctenophore lineages. However, NOS could be secondarily lost in many other ctenophores, including Pleurobrachia and Beroe. In Mnemiopsis leidyi, NOS is present both in adult tissues and differentially expressed in later embryonic stages suggesting the involvement of NO in developmental mechanisms. Ctenophores also possess soluble guanylyl cyclases as potential NO receptors with weak but differential expression across tissues. Combined, these data indicate that the canonical NO-cGMP signaling pathways existed in the common ancestor of animals and could be involved in the control of morphogenesis, cilia activities, feeding and different behaviors. |
format | Online Article Text |
id | pubmed-10073611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100736112023-04-06 Nitric oxide signaling in ctenophores Moroz, Leonid L. Mukherjee, Krishanu Romanova, Daria Y. Front Neurosci Neuroscience Nitric oxide (NO) is one of the most ancient and versatile signal molecules across all domains of life. NO signaling might also play an essential role in the origin of animal organization. Yet, practically nothing is known about the distribution and functions of NO-dependent signaling pathways in representatives of early branching metazoans such as Ctenophora. Here, we explore the presence and organization of NO signaling components using Mnemiopsis and kin as essential reference species. We show that NO synthase (NOS) is present in at least eight ctenophore species, including Euplokamis and Coeloplana, representing the most basal ctenophore lineages. However, NOS could be secondarily lost in many other ctenophores, including Pleurobrachia and Beroe. In Mnemiopsis leidyi, NOS is present both in adult tissues and differentially expressed in later embryonic stages suggesting the involvement of NO in developmental mechanisms. Ctenophores also possess soluble guanylyl cyclases as potential NO receptors with weak but differential expression across tissues. Combined, these data indicate that the canonical NO-cGMP signaling pathways existed in the common ancestor of animals and could be involved in the control of morphogenesis, cilia activities, feeding and different behaviors. Frontiers Media S.A. 2023-03-22 /pmc/articles/PMC10073611/ /pubmed/37034176 http://dx.doi.org/10.3389/fnins.2023.1125433 Text en Copyright © 2023 Moroz, Mukherjee and Romanova. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Moroz, Leonid L. Mukherjee, Krishanu Romanova, Daria Y. Nitric oxide signaling in ctenophores |
title | Nitric oxide signaling in ctenophores |
title_full | Nitric oxide signaling in ctenophores |
title_fullStr | Nitric oxide signaling in ctenophores |
title_full_unstemmed | Nitric oxide signaling in ctenophores |
title_short | Nitric oxide signaling in ctenophores |
title_sort | nitric oxide signaling in ctenophores |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073611/ https://www.ncbi.nlm.nih.gov/pubmed/37034176 http://dx.doi.org/10.3389/fnins.2023.1125433 |
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