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Maternal provisions in type 1 diabetes: Evidence for both protective & pathogenic potential

Maternal influences on the immune health and development of an infant begin in utero and continue well into the postnatal period, shaping and educating the child’s maturing immune system. Two maternal provisions include early microbial colonizers to initiate microbiota establishment and the transfer...

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Autores principales: Strachan, Erin, Clemente-Casares, Xavier, Tsai, Sue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073710/
https://www.ncbi.nlm.nih.gov/pubmed/37033940
http://dx.doi.org/10.3389/fimmu.2023.1146082
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author Strachan, Erin
Clemente-Casares, Xavier
Tsai, Sue
author_facet Strachan, Erin
Clemente-Casares, Xavier
Tsai, Sue
author_sort Strachan, Erin
collection PubMed
description Maternal influences on the immune health and development of an infant begin in utero and continue well into the postnatal period, shaping and educating the child’s maturing immune system. Two maternal provisions include early microbial colonizers to initiate microbiota establishment and the transfer of antibodies from mother to baby. Maternal antibodies are a result of a lifetime of antigenic experience, reflecting the infection history, health and environmental exposure of the mother. These same factors are strong influencers of the microbiota, inexorably linking the two. Together, these provisions help to educate the developing neonatal immune system and shape lymphocyte repertoires, establishing a role for external environmental influences even before birth. In the context of autoimmunity, the transfer of maternal autoantibodies has the potential to be harmful for the child, sometimes targeting tissues and cells with devastating consequences. Curiously, this does not seem to apply to maternal autoantibody transfer in type 1 diabetes (T1D). Moreover, despite the rising prevalence of the disease, little research has been conducted on the effects of maternal dysbiosis or antibody transfer from an affected mother to her offspring and thus their relevance to disease development in the offspring remains unclear. This review seeks to provide a thorough evaluation of the role of maternal microorganisms and antibodies within the context of T1D, exploring both their pathogenic and protective potential. Although a definitive understanding of their significance in infant T1D development remains elusive at present, we endeavor to present what has been learned with the goal of spurring further interest in this important and intriguing question.
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spelling pubmed-100737102023-04-06 Maternal provisions in type 1 diabetes: Evidence for both protective & pathogenic potential Strachan, Erin Clemente-Casares, Xavier Tsai, Sue Front Immunol Immunology Maternal influences on the immune health and development of an infant begin in utero and continue well into the postnatal period, shaping and educating the child’s maturing immune system. Two maternal provisions include early microbial colonizers to initiate microbiota establishment and the transfer of antibodies from mother to baby. Maternal antibodies are a result of a lifetime of antigenic experience, reflecting the infection history, health and environmental exposure of the mother. These same factors are strong influencers of the microbiota, inexorably linking the two. Together, these provisions help to educate the developing neonatal immune system and shape lymphocyte repertoires, establishing a role for external environmental influences even before birth. In the context of autoimmunity, the transfer of maternal autoantibodies has the potential to be harmful for the child, sometimes targeting tissues and cells with devastating consequences. Curiously, this does not seem to apply to maternal autoantibody transfer in type 1 diabetes (T1D). Moreover, despite the rising prevalence of the disease, little research has been conducted on the effects of maternal dysbiosis or antibody transfer from an affected mother to her offspring and thus their relevance to disease development in the offspring remains unclear. This review seeks to provide a thorough evaluation of the role of maternal microorganisms and antibodies within the context of T1D, exploring both their pathogenic and protective potential. Although a definitive understanding of their significance in infant T1D development remains elusive at present, we endeavor to present what has been learned with the goal of spurring further interest in this important and intriguing question. Frontiers Media S.A. 2023-03-22 /pmc/articles/PMC10073710/ /pubmed/37033940 http://dx.doi.org/10.3389/fimmu.2023.1146082 Text en Copyright © 2023 Strachan, Clemente-Casares and Tsai https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Strachan, Erin
Clemente-Casares, Xavier
Tsai, Sue
Maternal provisions in type 1 diabetes: Evidence for both protective & pathogenic potential
title Maternal provisions in type 1 diabetes: Evidence for both protective & pathogenic potential
title_full Maternal provisions in type 1 diabetes: Evidence for both protective & pathogenic potential
title_fullStr Maternal provisions in type 1 diabetes: Evidence for both protective & pathogenic potential
title_full_unstemmed Maternal provisions in type 1 diabetes: Evidence for both protective & pathogenic potential
title_short Maternal provisions in type 1 diabetes: Evidence for both protective & pathogenic potential
title_sort maternal provisions in type 1 diabetes: evidence for both protective & pathogenic potential
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073710/
https://www.ncbi.nlm.nih.gov/pubmed/37033940
http://dx.doi.org/10.3389/fimmu.2023.1146082
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