O-GlcNAcylation-induced GSK-3β activation deteriorates pressure overload-induced heart failure via lack of compensatory cardiac hypertrophy in mice

O-GlcNAc transferase (OGT) modulates many functions of proteins via O-GlcNAcylation that adds O-linked β-N-acetylglucosamine (O-GlcNAc) to the serine/threonine residues of proteins. However, the role of O-GlcNAcylation in cardiac remodeling and function is not fully understood. To examine the effect...

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Detalles Bibliográficos
Autores principales: Matsuno, Mahito, Yokoe, Shunichi, Nagatsuka, Takehiro, Morihara, Hirofumi, Moriwaki, Kazumasa, Asahi, Michio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073727/
https://www.ncbi.nlm.nih.gov/pubmed/37033243
http://dx.doi.org/10.3389/fendo.2023.1122125

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