Complement activation and increased anaphylatoxin receptor expression are associated with cortical grey matter lesions and the compartmentalised inflammatory response of multiple sclerosis

BACKGROUND: The extent of cortical pathology is an important determinant of multiple sclerosis (MS) severity. Cortical demyelination and neurodegeneration are related to inflammation of the overlying leptomeninges, a more inflammatory CSF milieu and with parenchymal microglia and astroglia activatio...

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Detalles Bibliográficos
Autores principales: Evans, Rhian, Watkins, Lewis M., Hawkins, Kristen, Santiago, Gabriella, Demetriou, Constantinos, Naughton, Michelle, Dittmer, Marie, Rees, Mark I., Fitzgerald, Denise, Morgan, B. Paul, Neal, James W., Howell, Owain W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073739/
https://www.ncbi.nlm.nih.gov/pubmed/37032838
http://dx.doi.org/10.3389/fncel.2023.1094106

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