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Hyperhomocysteinemia and pregnancy outcomes in women with polycystic ovary syndrome: A case-control study

BACKGROUND: One of the reproductive medicine challenges is to determine the role of hyperhomocysteinemia in the pathogenesis of polycystic ovary syndrome (PCOS), especially in women with recurrent pregnancy loss (RPL). OBJECTIVE: Determine the correlation between hyperhomocysteinemia and pregnancy o...

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Autores principales: Asanidze, Elene, Kristesashvili, Jenaro, Parunashvili, Nino, Urjumelashvili, Manana, Tsetskhladze, Zurab, Asanidze, Aleksandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Knowledge E 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073870/
https://www.ncbi.nlm.nih.gov/pubmed/37034292
http://dx.doi.org/10.18502/ijrm.v21i2.12807
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author Asanidze, Elene
Kristesashvili, Jenaro
Parunashvili, Nino
Urjumelashvili, Manana
Tsetskhladze, Zurab
Asanidze, Aleksandre
author_facet Asanidze, Elene
Kristesashvili, Jenaro
Parunashvili, Nino
Urjumelashvili, Manana
Tsetskhladze, Zurab
Asanidze, Aleksandre
author_sort Asanidze, Elene
collection PubMed
description BACKGROUND: One of the reproductive medicine challenges is to determine the role of hyperhomocysteinemia in the pathogenesis of polycystic ovary syndrome (PCOS), especially in women with recurrent pregnancy loss (RPL). OBJECTIVE: Determine the correlation between hyperhomocysteinemia and pregnancy outcome in women with PCOS. MATERIALS AND METHODS: This case-control study involved 245 women (20-30 yr) and was conducted in Georgia, Tbilisi from 2019-2022. Of these, 175 were women with PCOS (study group) and 70 were healthy women (control group). Women with PCOS were divided into group I with RPL (n = 90), and group II with live births (n = 85). Group I was divided into subgroups A and B with and without insulin resistance. The investigation measured homocysteine (Hcy), follicle-stimulating, luteinizing, anti-Mullerian hormones, total and free testosterone were determined. To determine the ovarian volume and antral follicle count, participants also underwent an ultrasound examination. RESULTS: In women with PCOS, the average Hcy level was significantly higher than in the controls, p [Formula: see text] 0.05. In group I, the average Hcy level was significantly higher than in group II and controls, p [Formula: see text] 0.05. There was no significant difference in average Hcy level between group II and controls. The average Hcy level in group I, subgroup A was significantly higher than in subgroup B, p [Formula: see text] 0.05. The average total, free testosterone levels, and homeostatic model assessment-insulin resistance levels (HOMA-IR) in group I was significantly higher than in group II and controls. HOMA-IR in group II and controls did not differ significantly. The average anti-Mullerian hormone levels in women with PCOS were significantly higher than controls, p [Formula: see text] 0.05. No significant difference was observed in average anti-Mullerian hormone level, ovarian volume, antral follicle count, and body mass index between the comparison groups of PCOS. In group I, a positive correlation between Hcy with HOMA-IR was detected. CONCLUSION: Serum Hcy levels are elevated in women with PCOS and RPL, which correlates with their insulin resistance status.
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spelling pubmed-100738702023-04-06 Hyperhomocysteinemia and pregnancy outcomes in women with polycystic ovary syndrome: A case-control study Asanidze, Elene Kristesashvili, Jenaro Parunashvili, Nino Urjumelashvili, Manana Tsetskhladze, Zurab Asanidze, Aleksandre Int J Reprod Biomed Original Article BACKGROUND: One of the reproductive medicine challenges is to determine the role of hyperhomocysteinemia in the pathogenesis of polycystic ovary syndrome (PCOS), especially in women with recurrent pregnancy loss (RPL). OBJECTIVE: Determine the correlation between hyperhomocysteinemia and pregnancy outcome in women with PCOS. MATERIALS AND METHODS: This case-control study involved 245 women (20-30 yr) and was conducted in Georgia, Tbilisi from 2019-2022. Of these, 175 were women with PCOS (study group) and 70 were healthy women (control group). Women with PCOS were divided into group I with RPL (n = 90), and group II with live births (n = 85). Group I was divided into subgroups A and B with and without insulin resistance. The investigation measured homocysteine (Hcy), follicle-stimulating, luteinizing, anti-Mullerian hormones, total and free testosterone were determined. To determine the ovarian volume and antral follicle count, participants also underwent an ultrasound examination. RESULTS: In women with PCOS, the average Hcy level was significantly higher than in the controls, p [Formula: see text] 0.05. In group I, the average Hcy level was significantly higher than in group II and controls, p [Formula: see text] 0.05. There was no significant difference in average Hcy level between group II and controls. The average Hcy level in group I, subgroup A was significantly higher than in subgroup B, p [Formula: see text] 0.05. The average total, free testosterone levels, and homeostatic model assessment-insulin resistance levels (HOMA-IR) in group I was significantly higher than in group II and controls. HOMA-IR in group II and controls did not differ significantly. The average anti-Mullerian hormone levels in women with PCOS were significantly higher than controls, p [Formula: see text] 0.05. No significant difference was observed in average anti-Mullerian hormone level, ovarian volume, antral follicle count, and body mass index between the comparison groups of PCOS. In group I, a positive correlation between Hcy with HOMA-IR was detected. CONCLUSION: Serum Hcy levels are elevated in women with PCOS and RPL, which correlates with their insulin resistance status. Knowledge E 2023-03-08 /pmc/articles/PMC10073870/ /pubmed/37034292 http://dx.doi.org/10.18502/ijrm.v21i2.12807 Text en Copyright © 2023 Asanidze et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Asanidze, Elene
Kristesashvili, Jenaro
Parunashvili, Nino
Urjumelashvili, Manana
Tsetskhladze, Zurab
Asanidze, Aleksandre
Hyperhomocysteinemia and pregnancy outcomes in women with polycystic ovary syndrome: A case-control study
title Hyperhomocysteinemia and pregnancy outcomes in women with polycystic ovary syndrome: A case-control study
title_full Hyperhomocysteinemia and pregnancy outcomes in women with polycystic ovary syndrome: A case-control study
title_fullStr Hyperhomocysteinemia and pregnancy outcomes in women with polycystic ovary syndrome: A case-control study
title_full_unstemmed Hyperhomocysteinemia and pregnancy outcomes in women with polycystic ovary syndrome: A case-control study
title_short Hyperhomocysteinemia and pregnancy outcomes in women with polycystic ovary syndrome: A case-control study
title_sort hyperhomocysteinemia and pregnancy outcomes in women with polycystic ovary syndrome: a case-control study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073870/
https://www.ncbi.nlm.nih.gov/pubmed/37034292
http://dx.doi.org/10.18502/ijrm.v21i2.12807
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