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Hyperhomocysteinemia and pregnancy outcomes in women with polycystic ovary syndrome: A case-control study
BACKGROUND: One of the reproductive medicine challenges is to determine the role of hyperhomocysteinemia in the pathogenesis of polycystic ovary syndrome (PCOS), especially in women with recurrent pregnancy loss (RPL). OBJECTIVE: Determine the correlation between hyperhomocysteinemia and pregnancy o...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Knowledge E
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073870/ https://www.ncbi.nlm.nih.gov/pubmed/37034292 http://dx.doi.org/10.18502/ijrm.v21i2.12807 |
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author | Asanidze, Elene Kristesashvili, Jenaro Parunashvili, Nino Urjumelashvili, Manana Tsetskhladze, Zurab Asanidze, Aleksandre |
author_facet | Asanidze, Elene Kristesashvili, Jenaro Parunashvili, Nino Urjumelashvili, Manana Tsetskhladze, Zurab Asanidze, Aleksandre |
author_sort | Asanidze, Elene |
collection | PubMed |
description | BACKGROUND: One of the reproductive medicine challenges is to determine the role of hyperhomocysteinemia in the pathogenesis of polycystic ovary syndrome (PCOS), especially in women with recurrent pregnancy loss (RPL). OBJECTIVE: Determine the correlation between hyperhomocysteinemia and pregnancy outcome in women with PCOS. MATERIALS AND METHODS: This case-control study involved 245 women (20-30 yr) and was conducted in Georgia, Tbilisi from 2019-2022. Of these, 175 were women with PCOS (study group) and 70 were healthy women (control group). Women with PCOS were divided into group I with RPL (n = 90), and group II with live births (n = 85). Group I was divided into subgroups A and B with and without insulin resistance. The investigation measured homocysteine (Hcy), follicle-stimulating, luteinizing, anti-Mullerian hormones, total and free testosterone were determined. To determine the ovarian volume and antral follicle count, participants also underwent an ultrasound examination. RESULTS: In women with PCOS, the average Hcy level was significantly higher than in the controls, p [Formula: see text] 0.05. In group I, the average Hcy level was significantly higher than in group II and controls, p [Formula: see text] 0.05. There was no significant difference in average Hcy level between group II and controls. The average Hcy level in group I, subgroup A was significantly higher than in subgroup B, p [Formula: see text] 0.05. The average total, free testosterone levels, and homeostatic model assessment-insulin resistance levels (HOMA-IR) in group I was significantly higher than in group II and controls. HOMA-IR in group II and controls did not differ significantly. The average anti-Mullerian hormone levels in women with PCOS were significantly higher than controls, p [Formula: see text] 0.05. No significant difference was observed in average anti-Mullerian hormone level, ovarian volume, antral follicle count, and body mass index between the comparison groups of PCOS. In group I, a positive correlation between Hcy with HOMA-IR was detected. CONCLUSION: Serum Hcy levels are elevated in women with PCOS and RPL, which correlates with their insulin resistance status. |
format | Online Article Text |
id | pubmed-10073870 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Knowledge E |
record_format | MEDLINE/PubMed |
spelling | pubmed-100738702023-04-06 Hyperhomocysteinemia and pregnancy outcomes in women with polycystic ovary syndrome: A case-control study Asanidze, Elene Kristesashvili, Jenaro Parunashvili, Nino Urjumelashvili, Manana Tsetskhladze, Zurab Asanidze, Aleksandre Int J Reprod Biomed Original Article BACKGROUND: One of the reproductive medicine challenges is to determine the role of hyperhomocysteinemia in the pathogenesis of polycystic ovary syndrome (PCOS), especially in women with recurrent pregnancy loss (RPL). OBJECTIVE: Determine the correlation between hyperhomocysteinemia and pregnancy outcome in women with PCOS. MATERIALS AND METHODS: This case-control study involved 245 women (20-30 yr) and was conducted in Georgia, Tbilisi from 2019-2022. Of these, 175 were women with PCOS (study group) and 70 were healthy women (control group). Women with PCOS were divided into group I with RPL (n = 90), and group II with live births (n = 85). Group I was divided into subgroups A and B with and without insulin resistance. The investigation measured homocysteine (Hcy), follicle-stimulating, luteinizing, anti-Mullerian hormones, total and free testosterone were determined. To determine the ovarian volume and antral follicle count, participants also underwent an ultrasound examination. RESULTS: In women with PCOS, the average Hcy level was significantly higher than in the controls, p [Formula: see text] 0.05. In group I, the average Hcy level was significantly higher than in group II and controls, p [Formula: see text] 0.05. There was no significant difference in average Hcy level between group II and controls. The average Hcy level in group I, subgroup A was significantly higher than in subgroup B, p [Formula: see text] 0.05. The average total, free testosterone levels, and homeostatic model assessment-insulin resistance levels (HOMA-IR) in group I was significantly higher than in group II and controls. HOMA-IR in group II and controls did not differ significantly. The average anti-Mullerian hormone levels in women with PCOS were significantly higher than controls, p [Formula: see text] 0.05. No significant difference was observed in average anti-Mullerian hormone level, ovarian volume, antral follicle count, and body mass index between the comparison groups of PCOS. In group I, a positive correlation between Hcy with HOMA-IR was detected. CONCLUSION: Serum Hcy levels are elevated in women with PCOS and RPL, which correlates with their insulin resistance status. Knowledge E 2023-03-08 /pmc/articles/PMC10073870/ /pubmed/37034292 http://dx.doi.org/10.18502/ijrm.v21i2.12807 Text en Copyright © 2023 Asanidze et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Asanidze, Elene Kristesashvili, Jenaro Parunashvili, Nino Urjumelashvili, Manana Tsetskhladze, Zurab Asanidze, Aleksandre Hyperhomocysteinemia and pregnancy outcomes in women with polycystic ovary syndrome: A case-control study |
title | Hyperhomocysteinemia and pregnancy outcomes in women with polycystic ovary syndrome: A case-control study |
title_full | Hyperhomocysteinemia and pregnancy outcomes in women with polycystic ovary syndrome: A case-control study |
title_fullStr | Hyperhomocysteinemia and pregnancy outcomes in women with polycystic ovary syndrome: A case-control study |
title_full_unstemmed | Hyperhomocysteinemia and pregnancy outcomes in women with polycystic ovary syndrome: A case-control study |
title_short | Hyperhomocysteinemia and pregnancy outcomes in women with polycystic ovary syndrome: A case-control study |
title_sort | hyperhomocysteinemia and pregnancy outcomes in women with polycystic ovary syndrome: a case-control study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073870/ https://www.ncbi.nlm.nih.gov/pubmed/37034292 http://dx.doi.org/10.18502/ijrm.v21i2.12807 |
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