Reprogramming of Mitochondrial Respiratory Chain Complex by Targeting SIRT3‐COX4I2 Axis Attenuates Osteoarthritis Progression (Adv. Sci. 10/2023)

Mitochondrial Reprogramming in Osteoarthritis The Mengtian and Wentian lab modules docked with Tianhe core module after entering the planned orbit. The successful docking boosts the construction of Tiangong space station project. In article number 2206144, Huilin Yang, Fan He, Xuesong Zhu, and co‐wo...

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Autores principales: Zhang, Yijian, Liu, Yang, Hou, Mingzhuang, Xia, Xiaowei, Liu, Junlin, Xu, Yong, Shi, Qin, Zhang, Zhongmin, Wang, Liang, Shen, Yifan, Yang, Huilin, He, Fan, Zhu, Xuesong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Inside Back Cover
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074060/
http://dx.doi.org/10.1002/advs.202370059
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author Zhang, Yijian
Liu, Yang
Hou, Mingzhuang
Xia, Xiaowei
Liu, Junlin
Xu, Yong
Shi, Qin
Zhang, Zhongmin
Wang, Liang
Shen, Yifan
Yang, Huilin
He, Fan
Zhu, Xuesong
author_facet Zhang, Yijian
Liu, Yang
Hou, Mingzhuang
Xia, Xiaowei
Liu, Junlin
Xu, Yong
Shi, Qin
Zhang, Zhongmin
Wang, Liang
Shen, Yifan
Yang, Huilin
He, Fan
Zhu, Xuesong
author_sort Zhang, Yijian
collection PubMed
description Mitochondrial Reprogramming in Osteoarthritis The Mengtian and Wentian lab modules docked with Tianhe core module after entering the planned orbit. The successful docking boosts the construction of Tiangong space station project. In article number 2206144, Huilin Yang, Fan He, Xuesong Zhu, and co‐workers uncovered that SIRT3 reprograms the mitochondrial respiratory chain complex via targeted deacetylation of COX4I2 to protect against osteoarthritis progression. Just like the satellite docking for exploring cosmic mysteries, the activation of SIRT3‐COX4I2 axis in mitochondria sheds new light on the pathogenesis of osteoarthritis. [Image: see text]
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spelling pubmed-100740602023-04-06 Reprogramming of Mitochondrial Respiratory Chain Complex by Targeting SIRT3‐COX4I2 Axis Attenuates Osteoarthritis Progression (Adv. Sci. 10/2023) Zhang, Yijian Liu, Yang Hou, Mingzhuang Xia, Xiaowei Liu, Junlin Xu, Yong Shi, Qin Zhang, Zhongmin Wang, Liang Shen, Yifan Yang, Huilin He, Fan Zhu, Xuesong Adv Sci (Weinh) Inside Back Cover Mitochondrial Reprogramming in Osteoarthritis The Mengtian and Wentian lab modules docked with Tianhe core module after entering the planned orbit. The successful docking boosts the construction of Tiangong space station project. In article number 2206144, Huilin Yang, Fan He, Xuesong Zhu, and co‐workers uncovered that SIRT3 reprograms the mitochondrial respiratory chain complex via targeted deacetylation of COX4I2 to protect against osteoarthritis progression. Just like the satellite docking for exploring cosmic mysteries, the activation of SIRT3‐COX4I2 axis in mitochondria sheds new light on the pathogenesis of osteoarthritis. [Image: see text] John Wiley and Sons Inc. 2023-04-05 /pmc/articles/PMC10074060/ http://dx.doi.org/10.1002/advs.202370059 Text en © 2023 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Inside Back Cover
Zhang, Yijian
Liu, Yang
Hou, Mingzhuang
Xia, Xiaowei
Liu, Junlin
Xu, Yong
Shi, Qin
Zhang, Zhongmin
Wang, Liang
Shen, Yifan
Yang, Huilin
He, Fan
Zhu, Xuesong
Reprogramming of Mitochondrial Respiratory Chain Complex by Targeting SIRT3‐COX4I2 Axis Attenuates Osteoarthritis Progression (Adv. Sci. 10/2023)
title Reprogramming of Mitochondrial Respiratory Chain Complex by Targeting SIRT3‐COX4I2 Axis Attenuates Osteoarthritis Progression (Adv. Sci. 10/2023)
title_full Reprogramming of Mitochondrial Respiratory Chain Complex by Targeting SIRT3‐COX4I2 Axis Attenuates Osteoarthritis Progression (Adv. Sci. 10/2023)
title_fullStr Reprogramming of Mitochondrial Respiratory Chain Complex by Targeting SIRT3‐COX4I2 Axis Attenuates Osteoarthritis Progression (Adv. Sci. 10/2023)
title_full_unstemmed Reprogramming of Mitochondrial Respiratory Chain Complex by Targeting SIRT3‐COX4I2 Axis Attenuates Osteoarthritis Progression (Adv. Sci. 10/2023)
title_short Reprogramming of Mitochondrial Respiratory Chain Complex by Targeting SIRT3‐COX4I2 Axis Attenuates Osteoarthritis Progression (Adv. Sci. 10/2023)
title_sort reprogramming of mitochondrial respiratory chain complex by targeting sirt3‐cox4i2 axis attenuates osteoarthritis progression (adv. sci. 10/2023)
topic Inside Back Cover
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074060/
http://dx.doi.org/10.1002/advs.202370059
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