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Chemical Control of CRISPR Gene Editing via Conditional Diacylation Crosslinking of Guide RNAs
Conditional control of RNA structure and function has emerged as an effective toolkit. Here, a strategy based on a one‐step introduction of diacylation linkers and azide groups on the 2′‐OH of RNA is advance. Selected from eight phosphine reagents, it is found that 2‐(diphenylphosphino)ethylamine ha...
Autores principales: | Lei, Huajun, Zeng, Tianying, Ye, Xiaofang, Fan, Ruochen, Xiong, Wei, Tian, Tian, Zhou, Xiang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074079/ https://www.ncbi.nlm.nih.gov/pubmed/36737854 http://dx.doi.org/10.1002/advs.202206433 |
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