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Low‐Cost, High‐Pressure‐Synthesized Oxygen‐Entrapping Materials to Improve Treatment of Solid Tumors
Tumor hypoxia drives resistance to many cancer therapies, including radiotherapy and chemotherapy. Methods that increase tumor oxygen pressures, such as hyperbaric oxygen therapy and microbubble infusion, are utilized to improve the responses to current standard‐of‐care therapies. However, key obsta...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074083/ https://www.ncbi.nlm.nih.gov/pubmed/36727291 http://dx.doi.org/10.1002/advs.202205995 |
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author | Bi, Jianling Witt, Emily Voltarelli, Vanessa A. Feig, Vivian R. Venkatachalam, Veena Boyce, Hannah McGovern, Megan Gutierrez, Wade R. Rytlewski, Jeffrey D. Bowman, Kate R. Rhodes, Ashley C. Cook, Austin N. Muller, Benjamin N. Smith, Matthew G. Ramos, Alexis Rebecca Panchal, Heena Dodd, Rebecca D. Henry, Michael D. Mailloux, Adam Traverso, Giovanni Otterbein, Leo E. Byrne, James D. |
author_facet | Bi, Jianling Witt, Emily Voltarelli, Vanessa A. Feig, Vivian R. Venkatachalam, Veena Boyce, Hannah McGovern, Megan Gutierrez, Wade R. Rytlewski, Jeffrey D. Bowman, Kate R. Rhodes, Ashley C. Cook, Austin N. Muller, Benjamin N. Smith, Matthew G. Ramos, Alexis Rebecca Panchal, Heena Dodd, Rebecca D. Henry, Michael D. Mailloux, Adam Traverso, Giovanni Otterbein, Leo E. Byrne, James D. |
author_sort | Bi, Jianling |
collection | PubMed |
description | Tumor hypoxia drives resistance to many cancer therapies, including radiotherapy and chemotherapy. Methods that increase tumor oxygen pressures, such as hyperbaric oxygen therapy and microbubble infusion, are utilized to improve the responses to current standard‐of‐care therapies. However, key obstacles remain, in particular delivery of oxygen at the appropriate dose and with optimal pharmacokinetics. Toward overcoming these hurdles, gas‐entrapping materials (GeMs) that are capable of tunable oxygen release are formulated. It is shown that injection or implantation of these materials into tumors can mitigate tumor hypoxia by delivering oxygen locally and that these GeMs enhance responsiveness to radiation and chemotherapy in multiple tumor types. This paper also demonstrates, by comparing an oxygen (O(2))‐GeM to a sham GeM, that the former generates an antitumorigenic and immunogenic tumor microenvironment in malignant peripheral nerve sheath tumors. Collectively the results indicate that the use of O(2)‐GeMs is promising as an adjunctive strategy for the treatment of solid tumors. |
format | Online Article Text |
id | pubmed-10074083 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100740832023-04-06 Low‐Cost, High‐Pressure‐Synthesized Oxygen‐Entrapping Materials to Improve Treatment of Solid Tumors Bi, Jianling Witt, Emily Voltarelli, Vanessa A. Feig, Vivian R. Venkatachalam, Veena Boyce, Hannah McGovern, Megan Gutierrez, Wade R. Rytlewski, Jeffrey D. Bowman, Kate R. Rhodes, Ashley C. Cook, Austin N. Muller, Benjamin N. Smith, Matthew G. Ramos, Alexis Rebecca Panchal, Heena Dodd, Rebecca D. Henry, Michael D. Mailloux, Adam Traverso, Giovanni Otterbein, Leo E. Byrne, James D. Adv Sci (Weinh) Research Articles Tumor hypoxia drives resistance to many cancer therapies, including radiotherapy and chemotherapy. Methods that increase tumor oxygen pressures, such as hyperbaric oxygen therapy and microbubble infusion, are utilized to improve the responses to current standard‐of‐care therapies. However, key obstacles remain, in particular delivery of oxygen at the appropriate dose and with optimal pharmacokinetics. Toward overcoming these hurdles, gas‐entrapping materials (GeMs) that are capable of tunable oxygen release are formulated. It is shown that injection or implantation of these materials into tumors can mitigate tumor hypoxia by delivering oxygen locally and that these GeMs enhance responsiveness to radiation and chemotherapy in multiple tumor types. This paper also demonstrates, by comparing an oxygen (O(2))‐GeM to a sham GeM, that the former generates an antitumorigenic and immunogenic tumor microenvironment in malignant peripheral nerve sheath tumors. Collectively the results indicate that the use of O(2)‐GeMs is promising as an adjunctive strategy for the treatment of solid tumors. John Wiley and Sons Inc. 2023-02-02 /pmc/articles/PMC10074083/ /pubmed/36727291 http://dx.doi.org/10.1002/advs.202205995 Text en © 2023 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Bi, Jianling Witt, Emily Voltarelli, Vanessa A. Feig, Vivian R. Venkatachalam, Veena Boyce, Hannah McGovern, Megan Gutierrez, Wade R. Rytlewski, Jeffrey D. Bowman, Kate R. Rhodes, Ashley C. Cook, Austin N. Muller, Benjamin N. Smith, Matthew G. Ramos, Alexis Rebecca Panchal, Heena Dodd, Rebecca D. Henry, Michael D. Mailloux, Adam Traverso, Giovanni Otterbein, Leo E. Byrne, James D. Low‐Cost, High‐Pressure‐Synthesized Oxygen‐Entrapping Materials to Improve Treatment of Solid Tumors |
title | Low‐Cost, High‐Pressure‐Synthesized Oxygen‐Entrapping Materials to Improve Treatment of Solid Tumors |
title_full | Low‐Cost, High‐Pressure‐Synthesized Oxygen‐Entrapping Materials to Improve Treatment of Solid Tumors |
title_fullStr | Low‐Cost, High‐Pressure‐Synthesized Oxygen‐Entrapping Materials to Improve Treatment of Solid Tumors |
title_full_unstemmed | Low‐Cost, High‐Pressure‐Synthesized Oxygen‐Entrapping Materials to Improve Treatment of Solid Tumors |
title_short | Low‐Cost, High‐Pressure‐Synthesized Oxygen‐Entrapping Materials to Improve Treatment of Solid Tumors |
title_sort | low‐cost, high‐pressure‐synthesized oxygen‐entrapping materials to improve treatment of solid tumors |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074083/ https://www.ncbi.nlm.nih.gov/pubmed/36727291 http://dx.doi.org/10.1002/advs.202205995 |
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