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Stretchable and Skin‐Attachable Electronic Device for Remotely Controlled Wearable Cancer Therapy

Surgery represents a primary clinical treatment of solid tumors. The high risk of local relapse typically requires frequent hospital visits for postoperative adjuvant therapy. Here, device designs and system integration of a stretchable electronic device for wearable cancer treatment are presented....

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Autores principales: Ma, Xiaohui, Wu, Xiaotong, Cao, Shitai, Zhao, Yinfeng, Lin, Yong, Xu, Yurui, Ning, Xinghai, Kong, Desheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074095/
https://www.ncbi.nlm.nih.gov/pubmed/36727804
http://dx.doi.org/10.1002/advs.202205343
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author Ma, Xiaohui
Wu, Xiaotong
Cao, Shitai
Zhao, Yinfeng
Lin, Yong
Xu, Yurui
Ning, Xinghai
Kong, Desheng
author_facet Ma, Xiaohui
Wu, Xiaotong
Cao, Shitai
Zhao, Yinfeng
Lin, Yong
Xu, Yurui
Ning, Xinghai
Kong, Desheng
author_sort Ma, Xiaohui
collection PubMed
description Surgery represents a primary clinical treatment of solid tumors. The high risk of local relapse typically requires frequent hospital visits for postoperative adjuvant therapy. Here, device designs and system integration of a stretchable electronic device for wearable cancer treatment are presented. The soft electronic patch harnesses compliant materials to achieve conformal and stable attachment to the surgical wound. A composite nanotextile dressing is laminated to the electronic patch to allow the on‐demand release of anticancer drugs under electro‐thermal actuation. An additional flexible circuit and a compact battery complete an untethered wearable system to execute remote therapeutic commands from a smartphone. The successful implementation of combined chemothermotherapy to inhibit tumor recurrence demonstrates the promising potential of stretchable electronics for advanced wearable therapies without interfering with daily activities.
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spelling pubmed-100740952023-04-06 Stretchable and Skin‐Attachable Electronic Device for Remotely Controlled Wearable Cancer Therapy Ma, Xiaohui Wu, Xiaotong Cao, Shitai Zhao, Yinfeng Lin, Yong Xu, Yurui Ning, Xinghai Kong, Desheng Adv Sci (Weinh) Research Articles Surgery represents a primary clinical treatment of solid tumors. The high risk of local relapse typically requires frequent hospital visits for postoperative adjuvant therapy. Here, device designs and system integration of a stretchable electronic device for wearable cancer treatment are presented. The soft electronic patch harnesses compliant materials to achieve conformal and stable attachment to the surgical wound. A composite nanotextile dressing is laminated to the electronic patch to allow the on‐demand release of anticancer drugs under electro‐thermal actuation. An additional flexible circuit and a compact battery complete an untethered wearable system to execute remote therapeutic commands from a smartphone. The successful implementation of combined chemothermotherapy to inhibit tumor recurrence demonstrates the promising potential of stretchable electronics for advanced wearable therapies without interfering with daily activities. John Wiley and Sons Inc. 2023-02-02 /pmc/articles/PMC10074095/ /pubmed/36727804 http://dx.doi.org/10.1002/advs.202205343 Text en © 2023 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Ma, Xiaohui
Wu, Xiaotong
Cao, Shitai
Zhao, Yinfeng
Lin, Yong
Xu, Yurui
Ning, Xinghai
Kong, Desheng
Stretchable and Skin‐Attachable Electronic Device for Remotely Controlled Wearable Cancer Therapy
title Stretchable and Skin‐Attachable Electronic Device for Remotely Controlled Wearable Cancer Therapy
title_full Stretchable and Skin‐Attachable Electronic Device for Remotely Controlled Wearable Cancer Therapy
title_fullStr Stretchable and Skin‐Attachable Electronic Device for Remotely Controlled Wearable Cancer Therapy
title_full_unstemmed Stretchable and Skin‐Attachable Electronic Device for Remotely Controlled Wearable Cancer Therapy
title_short Stretchable and Skin‐Attachable Electronic Device for Remotely Controlled Wearable Cancer Therapy
title_sort stretchable and skin‐attachable electronic device for remotely controlled wearable cancer therapy
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074095/
https://www.ncbi.nlm.nih.gov/pubmed/36727804
http://dx.doi.org/10.1002/advs.202205343
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