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Modeling mitochondrial DNA diseases: from base editing to pluripotent stem‐cell‐derived organoids
Mitochondrial DNA (mtDNA) diseases are multi‐systemic disorders caused by mutations affecting a fraction or the entirety of mtDNA copies. Currently, there are no approved therapies for the majority of mtDNA diseases. Challenges associated with engineering mtDNA have in fact hindered the study of mtD...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074100/ https://www.ncbi.nlm.nih.gov/pubmed/36876467 http://dx.doi.org/10.15252/embr.202255678 |