A mechanosensory defect in a C. elegans amyloid-beta glutamatergic neuron model is reversed following exposure to Salvia species extracts

Previous research has described promising neuroprotective and/or antioxidant properties for extracts derived from a few Salvia (sage) species. Here, six new Salvia species were isolated during flowering times from plants native to Turkey. Extracts were prepared and then examined for their potential...

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Detalles Bibliográficos
Autores principales: Schlein, Melissa L, Arituluk, Zekiye Ceren, Stephen, Cayman A, Caldwell, Guy A, Ciesla, Lukasz, Caldwell, Kim A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2023
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074171/
https://www.ncbi.nlm.nih.gov/pubmed/37033702
http://dx.doi.org/10.17912/micropub.biology.000780
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author Schlein, Melissa L
Arituluk, Zekiye Ceren
Stephen, Cayman A
Caldwell, Guy A
Ciesla, Lukasz
Caldwell, Kim A
author_facet Schlein, Melissa L
Arituluk, Zekiye Ceren
Stephen, Cayman A
Caldwell, Guy A
Ciesla, Lukasz
Caldwell, Kim A
author_sort Schlein, Melissa L
collection PubMed
description Previous research has described promising neuroprotective and/or antioxidant properties for extracts derived from a few Salvia (sage) species. Here, six new Salvia species were isolated during flowering times from plants native to Turkey. Extracts were prepared and then examined for their potential to rescue both anterior and posterior mechanosensory behavioral defects in a transgenic C. elegans Alzheimer’s disease model that expresses human amyloid-beta (Aβ) peptide (1-42) exclusively in the glutamatergic neurons. Extracts from all six Salvia species rescued anterior touch response defects while only three rescued posterior touch response defects, compared to the Aβ controls.
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spelling pubmed-100741712023-04-06 A mechanosensory defect in a C. elegans amyloid-beta glutamatergic neuron model is reversed following exposure to Salvia species extracts Schlein, Melissa L Arituluk, Zekiye Ceren Stephen, Cayman A Caldwell, Guy A Ciesla, Lukasz Caldwell, Kim A MicroPubl Biol New Finding Previous research has described promising neuroprotective and/or antioxidant properties for extracts derived from a few Salvia (sage) species. Here, six new Salvia species were isolated during flowering times from plants native to Turkey. Extracts were prepared and then examined for their potential to rescue both anterior and posterior mechanosensory behavioral defects in a transgenic C. elegans Alzheimer’s disease model that expresses human amyloid-beta (Aβ) peptide (1-42) exclusively in the glutamatergic neurons. Extracts from all six Salvia species rescued anterior touch response defects while only three rescued posterior touch response defects, compared to the Aβ controls. Caltech Library 2023-03-20 /pmc/articles/PMC10074171/ /pubmed/37033702 http://dx.doi.org/10.17912/micropub.biology.000780 Text en Copyright: © 2023 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle New Finding
Schlein, Melissa L
Arituluk, Zekiye Ceren
Stephen, Cayman A
Caldwell, Guy A
Ciesla, Lukasz
Caldwell, Kim A
A mechanosensory defect in a C. elegans amyloid-beta glutamatergic neuron model is reversed following exposure to Salvia species extracts
title A mechanosensory defect in a C. elegans amyloid-beta glutamatergic neuron model is reversed following exposure to Salvia species extracts
title_full A mechanosensory defect in a C. elegans amyloid-beta glutamatergic neuron model is reversed following exposure to Salvia species extracts
title_fullStr A mechanosensory defect in a C. elegans amyloid-beta glutamatergic neuron model is reversed following exposure to Salvia species extracts
title_full_unstemmed A mechanosensory defect in a C. elegans amyloid-beta glutamatergic neuron model is reversed following exposure to Salvia species extracts
title_short A mechanosensory defect in a C. elegans amyloid-beta glutamatergic neuron model is reversed following exposure to Salvia species extracts
title_sort mechanosensory defect in a c. elegans amyloid-beta glutamatergic neuron model is reversed following exposure to salvia species extracts
topic New Finding
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074171/
https://www.ncbi.nlm.nih.gov/pubmed/37033702
http://dx.doi.org/10.17912/micropub.biology.000780
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