The emerging role of ferroptosis in myocardial fibrosis of atrial fibrillation

INTRODUCTION: The aim of this study was to investigate the relationship between ferroptosis and myocardial fibrosis in atrial fibrillation (AF). METHODS: The patient’s left atrial appendage tissue was obtained in cardiac surgery. Sirius red staining, Prussian blue and Western blot were used to detec...

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Detalles Bibliográficos
Autores principales: Yue, Honghua, Zhan, Yujia, Zhang, Zheng, Liang, Weitao, Wu, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2023
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074302/
https://www.ncbi.nlm.nih.gov/pubmed/37034539
http://dx.doi.org/10.5114/aoms/160941
Descripción
Sumario:INTRODUCTION: The aim of this study was to investigate the relationship between ferroptosis and myocardial fibrosis in atrial fibrillation (AF). METHODS: The patient’s left atrial appendage tissue was obtained in cardiac surgery. Sirius red staining, Prussian blue and Western blot were used to detect staining to assess histological fibrosis and ferroptosis changes. RESULTS: There is a certain correlation between the degree of tissue fibrosis and ferroptosis in AF (r = 0.7763, p = 0.0004). The key proteins related to the regulation of ferroptosis were significantly abnormal in the AF group. CONCLUSIONS: Ferroptosis is involved in myocardial fibrosis of AF and is a potential target for the diagnosis, prevention and treatment of AF.

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