The emerging role of ferroptosis in myocardial fibrosis of atrial fibrillation

INTRODUCTION: The aim of this study was to investigate the relationship between ferroptosis and myocardial fibrosis in atrial fibrillation (AF). METHODS: The patient’s left atrial appendage tissue was obtained in cardiac surgery. Sirius red staining, Prussian blue and Western blot were used to detec...

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Autores principales: Yue, Honghua, Zhan, Yujia, Zhang, Zheng, Liang, Weitao, Wu, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2023
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074302/
https://www.ncbi.nlm.nih.gov/pubmed/37034539
http://dx.doi.org/10.5114/aoms/160941
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author Yue, Honghua
Zhan, Yujia
Zhang, Zheng
Liang, Weitao
Wu, Zhong
author_facet Yue, Honghua
Zhan, Yujia
Zhang, Zheng
Liang, Weitao
Wu, Zhong
author_sort Yue, Honghua
collection PubMed
description INTRODUCTION: The aim of this study was to investigate the relationship between ferroptosis and myocardial fibrosis in atrial fibrillation (AF). METHODS: The patient’s left atrial appendage tissue was obtained in cardiac surgery. Sirius red staining, Prussian blue and Western blot were used to detect staining to assess histological fibrosis and ferroptosis changes. RESULTS: There is a certain correlation between the degree of tissue fibrosis and ferroptosis in AF (r = 0.7763, p = 0.0004). The key proteins related to the regulation of ferroptosis were significantly abnormal in the AF group. CONCLUSIONS: Ferroptosis is involved in myocardial fibrosis of AF and is a potential target for the diagnosis, prevention and treatment of AF.
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spelling pubmed-100743022023-04-06 The emerging role of ferroptosis in myocardial fibrosis of atrial fibrillation Yue, Honghua Zhan, Yujia Zhang, Zheng Liang, Weitao Wu, Zhong Arch Med Sci Research Letter INTRODUCTION: The aim of this study was to investigate the relationship between ferroptosis and myocardial fibrosis in atrial fibrillation (AF). METHODS: The patient’s left atrial appendage tissue was obtained in cardiac surgery. Sirius red staining, Prussian blue and Western blot were used to detect staining to assess histological fibrosis and ferroptosis changes. RESULTS: There is a certain correlation between the degree of tissue fibrosis and ferroptosis in AF (r = 0.7763, p = 0.0004). The key proteins related to the regulation of ferroptosis were significantly abnormal in the AF group. CONCLUSIONS: Ferroptosis is involved in myocardial fibrosis of AF and is a potential target for the diagnosis, prevention and treatment of AF. Termedia Publishing House 2023-02-24 /pmc/articles/PMC10074302/ /pubmed/37034539 http://dx.doi.org/10.5114/aoms/160941 Text en Copyright: © 2023 Termedia & Banach https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Research Letter
Yue, Honghua
Zhan, Yujia
Zhang, Zheng
Liang, Weitao
Wu, Zhong
The emerging role of ferroptosis in myocardial fibrosis of atrial fibrillation
title The emerging role of ferroptosis in myocardial fibrosis of atrial fibrillation
title_full The emerging role of ferroptosis in myocardial fibrosis of atrial fibrillation
title_fullStr The emerging role of ferroptosis in myocardial fibrosis of atrial fibrillation
title_full_unstemmed The emerging role of ferroptosis in myocardial fibrosis of atrial fibrillation
title_short The emerging role of ferroptosis in myocardial fibrosis of atrial fibrillation
title_sort emerging role of ferroptosis in myocardial fibrosis of atrial fibrillation
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074302/
https://www.ncbi.nlm.nih.gov/pubmed/37034539
http://dx.doi.org/10.5114/aoms/160941
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