Impact of platelet endothelial aggregation receptor 1 genotypes and DNA methylation on platelet reactivity in patients with recurrent ischemic stroke treated with clopidogrel

INTRODUCTION: The aim of this study is to investigate the role of genetic variation and DNA methylation of PEAR1 rs12041331 in high on-treatment platelet reactivity (HPR) and recurrent ischemic stroke (RIS). METHODS: Genotype, methylation, and mRNA of PEAR1 rs12041331 were detected in patients with...

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Autores principales: Yang, Jiahui, Bao, Zhengjun, Hu, Guoyu, Luo, Xiaopeng, Zhao, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2023
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074304/
https://www.ncbi.nlm.nih.gov/pubmed/37034521
http://dx.doi.org/10.5114/aoms/159180
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author Yang, Jiahui
Bao, Zhengjun
Hu, Guoyu
Luo, Xiaopeng
Zhao, Zhen
author_facet Yang, Jiahui
Bao, Zhengjun
Hu, Guoyu
Luo, Xiaopeng
Zhao, Zhen
author_sort Yang, Jiahui
collection PubMed
description INTRODUCTION: The aim of this study is to investigate the role of genetic variation and DNA methylation of PEAR1 rs12041331 in high on-treatment platelet reactivity (HPR) and recurrent ischemic stroke (RIS). METHODS: Genotype, methylation, and mRNA of PEAR1 rs12041331 were detected in patients with cerebral ischemia, for the analysis of the effect of PEAR1 rs12041331 on HPR and RIS. RESULTS: The major G allele of PEAR1 rs12041331 was associated with hypermethylation, which was associated with HPR. This link was not observed for RIS. CONCLUSIONS: The PEAR1 rs12041331 genetic polymorphism and DNA methylation may be among the genetic factors affecting HPR. The correlation between PEAR1 and RIS needs to be studied further.
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spelling pubmed-100743042023-04-06 Impact of platelet endothelial aggregation receptor 1 genotypes and DNA methylation on platelet reactivity in patients with recurrent ischemic stroke treated with clopidogrel Yang, Jiahui Bao, Zhengjun Hu, Guoyu Luo, Xiaopeng Zhao, Zhen Arch Med Sci Research Letter INTRODUCTION: The aim of this study is to investigate the role of genetic variation and DNA methylation of PEAR1 rs12041331 in high on-treatment platelet reactivity (HPR) and recurrent ischemic stroke (RIS). METHODS: Genotype, methylation, and mRNA of PEAR1 rs12041331 were detected in patients with cerebral ischemia, for the analysis of the effect of PEAR1 rs12041331 on HPR and RIS. RESULTS: The major G allele of PEAR1 rs12041331 was associated with hypermethylation, which was associated with HPR. This link was not observed for RIS. CONCLUSIONS: The PEAR1 rs12041331 genetic polymorphism and DNA methylation may be among the genetic factors affecting HPR. The correlation between PEAR1 and RIS needs to be studied further. Termedia Publishing House 2023-02-16 /pmc/articles/PMC10074304/ /pubmed/37034521 http://dx.doi.org/10.5114/aoms/159180 Text en Copyright: © 2023 Termedia & Banach https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Research Letter
Yang, Jiahui
Bao, Zhengjun
Hu, Guoyu
Luo, Xiaopeng
Zhao, Zhen
Impact of platelet endothelial aggregation receptor 1 genotypes and DNA methylation on platelet reactivity in patients with recurrent ischemic stroke treated with clopidogrel
title Impact of platelet endothelial aggregation receptor 1 genotypes and DNA methylation on platelet reactivity in patients with recurrent ischemic stroke treated with clopidogrel
title_full Impact of platelet endothelial aggregation receptor 1 genotypes and DNA methylation on platelet reactivity in patients with recurrent ischemic stroke treated with clopidogrel
title_fullStr Impact of platelet endothelial aggregation receptor 1 genotypes and DNA methylation on platelet reactivity in patients with recurrent ischemic stroke treated with clopidogrel
title_full_unstemmed Impact of platelet endothelial aggregation receptor 1 genotypes and DNA methylation on platelet reactivity in patients with recurrent ischemic stroke treated with clopidogrel
title_short Impact of platelet endothelial aggregation receptor 1 genotypes and DNA methylation on platelet reactivity in patients with recurrent ischemic stroke treated with clopidogrel
title_sort impact of platelet endothelial aggregation receptor 1 genotypes and dna methylation on platelet reactivity in patients with recurrent ischemic stroke treated with clopidogrel
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074304/
https://www.ncbi.nlm.nih.gov/pubmed/37034521
http://dx.doi.org/10.5114/aoms/159180
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