Oxime@Zirconium-Metal–Organic Framework Hybrid Material as a Potential Antidote for Organophosphate Poisoning

[Image: see text] A novel material with dual activity toward organophosphate (OP) poisoning, based on Zr-MOF-808 and neutral oxime RS69N, has been prepared. The hybrid material has a significant drug payload (5.2 ± 0.9 oxime to MOF-808 molar ratio) and shows a sustained oxime release in simulated ph...

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Detalles Bibliográficos
Autores principales: González, Lydia, Martín-Romera, Javier D., Sánchez-Sánchez, Purificación, Navarro, Jorge A. R., Barea, Elisa, Maldonado, Carmen R., Carmona, Francisco J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074384/
https://www.ncbi.nlm.nih.gov/pubmed/36939843
http://dx.doi.org/10.1021/acs.inorgchem.3c00121
Descripción
Sumario:[Image: see text] A novel material with dual activity toward organophosphate (OP) poisoning, based on Zr-MOF-808 and neutral oxime RS69N, has been prepared. The hybrid material has a significant drug payload (5.2 ± 0.9 oxime to MOF-808 molar ratio) and shows a sustained oxime release in simulated physiological media, leading to the successful reactivation of OP-inhibited acetylcholinesterase. At the same time, the hybrid system presents an efficient and moderately fast removal rate of a toxic organophosphorus model compound (diisopropylfluorophosphate) from simulated physiological media (t(1/2) = 183 min; 95% removal rate after 24 h).

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