Novel N(SCF(3))(CF(3))-amines: synthesis, scalability and stability

We disclosed herein a straightforward strategy for the synthesis of unprecedented N-((trifluoromethyl)thio), N-(trifluoromethyl) amines using a combination of isothiocyanates with a fluoride source and an electrophilic trifluoromethylthiolation reagent. More interestingly, the scalability of the met...

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Detalles Bibliográficos
Autores principales: Yang, Yi, Saffon-Merceron, Nathalie, Vantourout, Julien C., Tlili, Anis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074438/
https://www.ncbi.nlm.nih.gov/pubmed/37035709
http://dx.doi.org/10.1039/d2sc06542h
Descripción
Sumario:We disclosed herein a straightforward strategy for the synthesis of unprecedented N-((trifluoromethyl)thio), N-(trifluoromethyl) amines using a combination of isothiocyanates with a fluoride source and an electrophilic trifluoromethylthiolation reagent. More interestingly, the scalability of the methodology has been demonstrated and the stability of the new motif has been studied.

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