Novel N(SCF(3))(CF(3))-amines: synthesis, scalability and stability

We disclosed herein a straightforward strategy for the synthesis of unprecedented N-((trifluoromethyl)thio), N-(trifluoromethyl) amines using a combination of isothiocyanates with a fluoride source and an electrophilic trifluoromethylthiolation reagent. More interestingly, the scalability of the met...

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Detalles Bibliográficos
Autores principales: Yang, Yi, Saffon-Merceron, Nathalie, Vantourout, Julien C., Tlili, Anis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074438/
https://www.ncbi.nlm.nih.gov/pubmed/37035709
http://dx.doi.org/10.1039/d2sc06542h
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author Yang, Yi
Saffon-Merceron, Nathalie
Vantourout, Julien C.
Tlili, Anis
author_facet Yang, Yi
Saffon-Merceron, Nathalie
Vantourout, Julien C.
Tlili, Anis
author_sort Yang, Yi
collection PubMed
description We disclosed herein a straightforward strategy for the synthesis of unprecedented N-((trifluoromethyl)thio), N-(trifluoromethyl) amines using a combination of isothiocyanates with a fluoride source and an electrophilic trifluoromethylthiolation reagent. More interestingly, the scalability of the methodology has been demonstrated and the stability of the new motif has been studied.
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spelling pubmed-100744382023-04-06 Novel N(SCF(3))(CF(3))-amines: synthesis, scalability and stability Yang, Yi Saffon-Merceron, Nathalie Vantourout, Julien C. Tlili, Anis Chem Sci Chemistry We disclosed herein a straightforward strategy for the synthesis of unprecedented N-((trifluoromethyl)thio), N-(trifluoromethyl) amines using a combination of isothiocyanates with a fluoride source and an electrophilic trifluoromethylthiolation reagent. More interestingly, the scalability of the methodology has been demonstrated and the stability of the new motif has been studied. The Royal Society of Chemistry 2023-03-13 /pmc/articles/PMC10074438/ /pubmed/37035709 http://dx.doi.org/10.1039/d2sc06542h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Yang, Yi
Saffon-Merceron, Nathalie
Vantourout, Julien C.
Tlili, Anis
Novel N(SCF(3))(CF(3))-amines: synthesis, scalability and stability
title Novel N(SCF(3))(CF(3))-amines: synthesis, scalability and stability
title_full Novel N(SCF(3))(CF(3))-amines: synthesis, scalability and stability
title_fullStr Novel N(SCF(3))(CF(3))-amines: synthesis, scalability and stability
title_full_unstemmed Novel N(SCF(3))(CF(3))-amines: synthesis, scalability and stability
title_short Novel N(SCF(3))(CF(3))-amines: synthesis, scalability and stability
title_sort novel n(scf(3))(cf(3))-amines: synthesis, scalability and stability
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074438/
https://www.ncbi.nlm.nih.gov/pubmed/37035709
http://dx.doi.org/10.1039/d2sc06542h
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AT tlilianis novelnscf3cf3aminessynthesisscalabilityandstability

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