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Synthesis of functionalized 2,3-diaminopropionates and their potential for directed monobactam biosynthesis

The N-sulfonated monobactams harbor considerable potential to combat emerging bacterial infections that are problematic to treat due to their metallo-β-lactamase mediated resistance against conventional β-lactam antibiotics. Herein, we report a divergent synthesis of C3-substituted 2,3-diaminopropio...

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Detalles Bibliográficos
Autores principales: Lichstrahl, Michael S., Kahlert, Lukas, Li, Rongfeng, Zandi, Trevor A., Yang, Jerry, Townsend, Craig. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074443/
https://www.ncbi.nlm.nih.gov/pubmed/37035696
http://dx.doi.org/10.1039/d2sc06893a