Promoters vs. telomeres: AP-endonuclease 1 interactions with abasic sites in G-quadruplex folds depend on topology

The DNA repair endonuclease APE1 is responsible for the cleavage of abasic sites (AP) in DNA as well as binding AP in promoter G-quadruplex (G4) folds in some genes to regulate transcription. The present studies focused on the topological properties of AP-bearing G4 folds and how they impact APE1 in...

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Detalles Bibliográficos
Autores principales: Howpay Manage, Shereen A., Zhu, Judy, Fleming, Aaron M., Burrows, Cynthia J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074553/
https://www.ncbi.nlm.nih.gov/pubmed/37034403
http://dx.doi.org/10.1039/d2cb00233g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074553/
https://www.ncbi.nlm.nih.gov/pubmed/37034403
http://dx.doi.org/10.1039/d2cb00233g

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