Role of T-box transcription factor 3 in gastric cancers

The expression of T-box transcription factor 3 (TBX3) has been identified in various cancers, including gastric cancers. Its role in breast cancers and melanomas has been intensively studied, and its contribution to the progression of cancers through suppressing senescence and promoting epithelial-m...

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Detalles Bibliográficos
Autores principales: Asano, Naoki, Imatani, Akira, Takeuchi, Akio, Saito, Masashi, Jin, Xiao-Yi, Hatta, Waku, Uno, Kaname, Koike, Tomoyuki, Masamune, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Minireviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10074946/
https://www.ncbi.nlm.nih.gov/pubmed/37035275
http://dx.doi.org/10.4291/wjgp.v14.i2.12
Descripción
Sumario:The expression of T-box transcription factor 3 (TBX3) has been identified in various cancers, including gastric cancers. Its role in breast cancers and melanomas has been intensively studied, and its contribution to the progression of cancers through suppressing senescence and promoting epithelial-mesenchymal transition has been reported. Recent reports on the role of TBX3 in gastric cancers have implied its involvement in gastric carcinogenesis. Considering its pivotal role in the initiation and progression of cancers, TBX3 could be a promising therapeutic target for gastric cancers.

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