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A Narrative Review of the Toxic Effects on Male Reproductive and Sexual Health of Chewing the Psychostimulant, Catha edulis (Khat)

Khat (Catha edulis Forsk) is a stimulating narcotic grown mainly in East and Southern Africa. The plant has a long history as a popular social behavior within these regions, and its active ingredient, cathinone, has been thought to cause an array of physical, psychological, and mental health complic...

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Autores principales: Alzahrani, Meshari A., Alsahli, Majed A., Alarifi, Fasial F., Hakami, Basel O., Alkeraithe, Fawaz W., Alhuqbani, Mohammed, Aldosari, Zyad, Aldosari, Omar, Almhmd, Abdalah Emad, Binsaleh, Saleh, Almannie, Raed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10075001/
https://www.ncbi.nlm.nih.gov/pubmed/37002591
http://dx.doi.org/10.12659/MSM.939455
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author Alzahrani, Meshari A.
Alsahli, Majed A.
Alarifi, Fasial F.
Hakami, Basel O.
Alkeraithe, Fawaz W.
Alhuqbani, Mohammed
Aldosari, Zyad
Aldosari, Omar
Almhmd, Abdalah Emad
Binsaleh, Saleh
Almannie, Raed
author_facet Alzahrani, Meshari A.
Alsahli, Majed A.
Alarifi, Fasial F.
Hakami, Basel O.
Alkeraithe, Fawaz W.
Alhuqbani, Mohammed
Aldosari, Zyad
Aldosari, Omar
Almhmd, Abdalah Emad
Binsaleh, Saleh
Almannie, Raed
author_sort Alzahrani, Meshari A.
collection PubMed
description Khat (Catha edulis Forsk) is a stimulating narcotic grown mainly in East and Southern Africa. The plant has a long history as a popular social behavior within these regions, and its active ingredient, cathinone, has been thought to cause an array of physical, psychological, and mental health complications. In 1980, the World Health Organization (WHO) classified it as an illicit substance due to the potential for psychological dependence. Subsequent investigations have found that its regular consumption can negatively impact the human central nervous system (CNS), systemic blood pressure, genitourinary system, and psychological health. This narrative review aims to discuss the reproductive toxicity and sexual dysfunction (SD) caused by regular khat usage in humans and experimental animals. Animal studies found dose-dependent impacts on male reproductive health: low levels increased testosterone production, whereas high levels had the opposite effects. Moderate intake was associated with reduced luteinizing hormone (LH) levels and heightened cortisol in blood plasma. In human studies, chronic users had dramatically lower semen volume, sperm motility, and count, as well as reduced libido or erectile dysfunction (ED). Khat can have serious implications for male fertility and sexual health: therefore, better understanding of its effects is paramount. This article aims to review the toxic effects on the male reproductive and sexual health of chewing the psychostimulant, Catha edulis (khat).
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spelling pubmed-100750012023-04-06 A Narrative Review of the Toxic Effects on Male Reproductive and Sexual Health of Chewing the Psychostimulant, Catha edulis (Khat) Alzahrani, Meshari A. Alsahli, Majed A. Alarifi, Fasial F. Hakami, Basel O. Alkeraithe, Fawaz W. Alhuqbani, Mohammed Aldosari, Zyad Aldosari, Omar Almhmd, Abdalah Emad Binsaleh, Saleh Almannie, Raed Med Sci Monit Epidemiology Khat (Catha edulis Forsk) is a stimulating narcotic grown mainly in East and Southern Africa. The plant has a long history as a popular social behavior within these regions, and its active ingredient, cathinone, has been thought to cause an array of physical, psychological, and mental health complications. In 1980, the World Health Organization (WHO) classified it as an illicit substance due to the potential for psychological dependence. Subsequent investigations have found that its regular consumption can negatively impact the human central nervous system (CNS), systemic blood pressure, genitourinary system, and psychological health. This narrative review aims to discuss the reproductive toxicity and sexual dysfunction (SD) caused by regular khat usage in humans and experimental animals. Animal studies found dose-dependent impacts on male reproductive health: low levels increased testosterone production, whereas high levels had the opposite effects. Moderate intake was associated with reduced luteinizing hormone (LH) levels and heightened cortisol in blood plasma. In human studies, chronic users had dramatically lower semen volume, sperm motility, and count, as well as reduced libido or erectile dysfunction (ED). Khat can have serious implications for male fertility and sexual health: therefore, better understanding of its effects is paramount. This article aims to review the toxic effects on the male reproductive and sexual health of chewing the psychostimulant, Catha edulis (khat). International Scientific Literature, Inc. 2023-04-01 /pmc/articles/PMC10075001/ /pubmed/37002591 http://dx.doi.org/10.12659/MSM.939455 Text en © Med Sci Monit, 2023 https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Epidemiology
Alzahrani, Meshari A.
Alsahli, Majed A.
Alarifi, Fasial F.
Hakami, Basel O.
Alkeraithe, Fawaz W.
Alhuqbani, Mohammed
Aldosari, Zyad
Aldosari, Omar
Almhmd, Abdalah Emad
Binsaleh, Saleh
Almannie, Raed
A Narrative Review of the Toxic Effects on Male Reproductive and Sexual Health of Chewing the Psychostimulant, Catha edulis (Khat)
title A Narrative Review of the Toxic Effects on Male Reproductive and Sexual Health of Chewing the Psychostimulant, Catha edulis (Khat)
title_full A Narrative Review of the Toxic Effects on Male Reproductive and Sexual Health of Chewing the Psychostimulant, Catha edulis (Khat)
title_fullStr A Narrative Review of the Toxic Effects on Male Reproductive and Sexual Health of Chewing the Psychostimulant, Catha edulis (Khat)
title_full_unstemmed A Narrative Review of the Toxic Effects on Male Reproductive and Sexual Health of Chewing the Psychostimulant, Catha edulis (Khat)
title_short A Narrative Review of the Toxic Effects on Male Reproductive and Sexual Health of Chewing the Psychostimulant, Catha edulis (Khat)
title_sort narrative review of the toxic effects on male reproductive and sexual health of chewing the psychostimulant, catha edulis (khat)
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10075001/
https://www.ncbi.nlm.nih.gov/pubmed/37002591
http://dx.doi.org/10.12659/MSM.939455
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