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AT1 receptor downregulation: A mechanism for improving glucose homeostasis

There is a pathophysiological correlation between arterial hypertension and diabetes mellitus, established since the pre-diabetic state in the entity known as insulin resistance. It is known that high concentrations of angiotensin-II enable chronic activation of the AT1 receptor, promoting sustained...

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Autores principales: Lopez, Diana L, Casillas, Oscar E, Jaramillo, Hiram J, Romero-Garcia, Tatiana, Vazquez-Jimenez, J. Gustavo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10075037/
https://www.ncbi.nlm.nih.gov/pubmed/37035227
http://dx.doi.org/10.4239/wjd.v14.i3.170
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author Lopez, Diana L
Casillas, Oscar E
Jaramillo, Hiram J
Romero-Garcia, Tatiana
Vazquez-Jimenez, J. Gustavo
author_facet Lopez, Diana L
Casillas, Oscar E
Jaramillo, Hiram J
Romero-Garcia, Tatiana
Vazquez-Jimenez, J. Gustavo
author_sort Lopez, Diana L
collection PubMed
description There is a pathophysiological correlation between arterial hypertension and diabetes mellitus, established since the pre-diabetic state in the entity known as insulin resistance. It is known that high concentrations of angiotensin-II enable chronic activation of the AT1 receptor, promoting sustained vasoconstriction and the consequent development of high blood pressure. Furthermore, the chronic activation of the AT1 receptor has been associated with the development of insulin resistance. From a molecular outlook, the AT1 receptor signaling pathway can activate the JNK kinase. Once activated, this kinase can block the insulin signaling pathway, favoring the resistance to this hormone. In accordance with the previously mentioned mechanisms, the negative regulation of the AT1 receptor could have beneficial effects in treating metabolic syndrome and type 2 diabetes mellitus. This review explains the clinical correlation of the metabolic response that diabetic patients present when receiving negatively regulatory drugs of the AT1 receptor.
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spelling pubmed-100750372023-04-06 AT1 receptor downregulation: A mechanism for improving glucose homeostasis Lopez, Diana L Casillas, Oscar E Jaramillo, Hiram J Romero-Garcia, Tatiana Vazquez-Jimenez, J. Gustavo World J Diabetes Minireviews There is a pathophysiological correlation between arterial hypertension and diabetes mellitus, established since the pre-diabetic state in the entity known as insulin resistance. It is known that high concentrations of angiotensin-II enable chronic activation of the AT1 receptor, promoting sustained vasoconstriction and the consequent development of high blood pressure. Furthermore, the chronic activation of the AT1 receptor has been associated with the development of insulin resistance. From a molecular outlook, the AT1 receptor signaling pathway can activate the JNK kinase. Once activated, this kinase can block the insulin signaling pathway, favoring the resistance to this hormone. In accordance with the previously mentioned mechanisms, the negative regulation of the AT1 receptor could have beneficial effects in treating metabolic syndrome and type 2 diabetes mellitus. This review explains the clinical correlation of the metabolic response that diabetic patients present when receiving negatively regulatory drugs of the AT1 receptor. Baishideng Publishing Group Inc 2023-03-15 2023-03-15 /pmc/articles/PMC10075037/ /pubmed/37035227 http://dx.doi.org/10.4239/wjd.v14.i3.170 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Minireviews
Lopez, Diana L
Casillas, Oscar E
Jaramillo, Hiram J
Romero-Garcia, Tatiana
Vazquez-Jimenez, J. Gustavo
AT1 receptor downregulation: A mechanism for improving glucose homeostasis
title AT1 receptor downregulation: A mechanism for improving glucose homeostasis
title_full AT1 receptor downregulation: A mechanism for improving glucose homeostasis
title_fullStr AT1 receptor downregulation: A mechanism for improving glucose homeostasis
title_full_unstemmed AT1 receptor downregulation: A mechanism for improving glucose homeostasis
title_short AT1 receptor downregulation: A mechanism for improving glucose homeostasis
title_sort at1 receptor downregulation: a mechanism for improving glucose homeostasis
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10075037/
https://www.ncbi.nlm.nih.gov/pubmed/37035227
http://dx.doi.org/10.4239/wjd.v14.i3.170
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