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Alzheimer’s disease risk after COVID-19: a view from the perspective of the infectious hypothesis of neurodegeneration

In light of the rising evidence of the association between viral and bacterial infections and neurodegeneration, we aimed at revisiting the infectious hypothesis of Alzheimer’s disease and analyzing the possible implications of COVID-19 neurological sequelae in long-term neurodegeneration. We wonder...

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Autores principales: Olivera, Eugenia, Sáez, Albany, Carniglia, Lila, Caruso, Carla, Lasaga, Mercedes, Durand, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10075115/
https://www.ncbi.nlm.nih.gov/pubmed/36571334
http://dx.doi.org/10.4103/1673-5374.360273
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author Olivera, Eugenia
Sáez, Albany
Carniglia, Lila
Caruso, Carla
Lasaga, Mercedes
Durand, Daniela
author_facet Olivera, Eugenia
Sáez, Albany
Carniglia, Lila
Caruso, Carla
Lasaga, Mercedes
Durand, Daniela
author_sort Olivera, Eugenia
collection PubMed
description In light of the rising evidence of the association between viral and bacterial infections and neurodegeneration, we aimed at revisiting the infectious hypothesis of Alzheimer’s disease and analyzing the possible implications of COVID-19 neurological sequelae in long-term neurodegeneration. We wondered how SARS-CoV-2 could be related to the amyloid-β cascade and how it could lead to the pathological hallmarks of the disease. We also predict a paradigm change in clinical medicine, which now has a great opportunity to conduct prospective surveillance of cognitive sequelae and progression to dementia in people who suffered severe infections together with other risk factors for Alzheimer’s disease.
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spelling pubmed-100751152023-04-06 Alzheimer’s disease risk after COVID-19: a view from the perspective of the infectious hypothesis of neurodegeneration Olivera, Eugenia Sáez, Albany Carniglia, Lila Caruso, Carla Lasaga, Mercedes Durand, Daniela Neural Regen Res Review In light of the rising evidence of the association between viral and bacterial infections and neurodegeneration, we aimed at revisiting the infectious hypothesis of Alzheimer’s disease and analyzing the possible implications of COVID-19 neurological sequelae in long-term neurodegeneration. We wondered how SARS-CoV-2 could be related to the amyloid-β cascade and how it could lead to the pathological hallmarks of the disease. We also predict a paradigm change in clinical medicine, which now has a great opportunity to conduct prospective surveillance of cognitive sequelae and progression to dementia in people who suffered severe infections together with other risk factors for Alzheimer’s disease. Wolters Kluwer - Medknow 2022-11-09 /pmc/articles/PMC10075115/ /pubmed/36571334 http://dx.doi.org/10.4103/1673-5374.360273 Text en Copyright: © Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review
Olivera, Eugenia
Sáez, Albany
Carniglia, Lila
Caruso, Carla
Lasaga, Mercedes
Durand, Daniela
Alzheimer’s disease risk after COVID-19: a view from the perspective of the infectious hypothesis of neurodegeneration
title Alzheimer’s disease risk after COVID-19: a view from the perspective of the infectious hypothesis of neurodegeneration
title_full Alzheimer’s disease risk after COVID-19: a view from the perspective of the infectious hypothesis of neurodegeneration
title_fullStr Alzheimer’s disease risk after COVID-19: a view from the perspective of the infectious hypothesis of neurodegeneration
title_full_unstemmed Alzheimer’s disease risk after COVID-19: a view from the perspective of the infectious hypothesis of neurodegeneration
title_short Alzheimer’s disease risk after COVID-19: a view from the perspective of the infectious hypothesis of neurodegeneration
title_sort alzheimer’s disease risk after covid-19: a view from the perspective of the infectious hypothesis of neurodegeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10075115/
https://www.ncbi.nlm.nih.gov/pubmed/36571334
http://dx.doi.org/10.4103/1673-5374.360273
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