Cargando…
The GPER Agonist LNS8801 Induces Mitotic Arrest and Apoptosis in Uveal Melanoma Cells
Uveal melanoma is the most common primary intraocular malignancy in adults and has a high incidence of metastatic disease. Current treatments have shown limited clinical activity in patients with uveal melanoma with metastasis and there is an urgent need for new effective therapies. Recent findings...
Autores principales: | Ambrosini, Grazia, Natale, Christopher A., Musi, Elgilda, Garyantes, Tina, Schwartz, Gary K. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for Cancer Research
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10075232/ https://www.ncbi.nlm.nih.gov/pubmed/37035582 http://dx.doi.org/10.1158/2767-9764.CRC-22-0399 |
Ejemplares similares
-
BRD4-targeted therapy induces Myc-independent cytotoxicity in Gnaq/11-mutatant uveal melanoma cells
por: Ambrosini, Grazia, et al.
Publicado: (2015) -
Impact of Combined mTOR and MEK Inhibition in Uveal Melanoma Is Driven by Tumor Genotype
por: Ho, Alan L., et al.
Publicado: (2012) -
LNS8801 inhibits Acute Myeloid Leukemia by Inducing the Production of Reactive Oxygen Species and Activating the Endoplasmic Reticulum Stress Pathway
por: Lee, Inyoung, et al.
Publicado: (2023) -
Transcriptional analysis of metastatic uveal melanoma survival nominates NRP1 as a therapeutic target
por: Bao, Riyue, et al.
Publicado: (2020) -
A Phase Ib Study of Sotrastaurin, a PKC Inhibitor, and Alpelisib, a PI3Kα Inhibitor, in Patients with Metastatic Uveal Melanoma
por: Shoushtari, Alexander N., et al.
Publicado: (2021)