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Urinary Phthalate Metabolites and Slow Walking Speed in the Korean Elderly Environmental Panel II Study

BACKGROUND: Previous epidemiological studies have suggested that phthalate exposure may contribute to neurocognitive and neurobehavioral disorders and decreased muscle strength and bone mass, all of which may be associated with reduced physical performance. Walking speed is a reliable assessment too...

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Autores principales: Yoon, Jeonggyo, García-Esquinas, Esther, Kim, Junghoon, Kwak, Jung Hyun, Kim, Hongsoo, Kim, Sungroul, Kim, Kyoung-Nam, Hong, Yun-Chul, Choi, Yoon-Hyeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Environmental Health Perspectives 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10075311/
https://www.ncbi.nlm.nih.gov/pubmed/37018009
http://dx.doi.org/10.1289/EHP10549
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author Yoon, Jeonggyo
García-Esquinas, Esther
Kim, Junghoon
Kwak, Jung Hyun
Kim, Hongsoo
Kim, Sungroul
Kim, Kyoung-Nam
Hong, Yun-Chul
Choi, Yoon-Hyeong
author_facet Yoon, Jeonggyo
García-Esquinas, Esther
Kim, Junghoon
Kwak, Jung Hyun
Kim, Hongsoo
Kim, Sungroul
Kim, Kyoung-Nam
Hong, Yun-Chul
Choi, Yoon-Hyeong
author_sort Yoon, Jeonggyo
collection PubMed
description BACKGROUND: Previous epidemiological studies have suggested that phthalate exposure may contribute to neurocognitive and neurobehavioral disorders and decreased muscle strength and bone mass, all of which may be associated with reduced physical performance. Walking speed is a reliable assessment tool for measuring physical performance in adults age 60 y and older. OBJECTIVE: We investigated associations between urinary phthalate metabolites and slowness of walking speed in community-dwelling adults ages 60–98 y. METHODS: We analyzed 1,190 older adults [range, 60–98 y of age; [Formula: see text] , [Formula: see text]] from the Korean Elderly Environmental Panel II study and measured repeatedly up to three times between 2012 and 2014. Phthalate exposure was estimated using the following phthalate metabolites in urine samples: mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-n-butyl phthalate (MnBP), mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), and mono-benzyl phthalate (MBzP). Slowness was defined as a walking speed of [Formula: see text]. We used logistic and linear regression models to evaluate the association between each urinary phthalate metabolite and slowness or walking-speed change. We also used Bayesian kernel machine regression (BKMR) to examine overall mixture effects on walking speed. RESULTS: At enrollment, MBzP levels were associated with an increased odds of slowness [odds ratio (OR) per doubling increase: 1.15, 95% confidence interval (CI): 1.02, 1.30; OR for the highest vs. lowest quartile: 2.20 (95% CI: 1.12, 4.35) with p-trend across [Formula: see text]]. In longitudinal analyses, MEHHP levels showed an increased risk of slowness [OR per doubling increase: 1.15 (95% CI: 1.02, 1.29), OR for the highest vs. lowest quartile: 1.47 (95% CI: 1.04, 2.06), [Formula: see text]]; whereas those with higher MnBP showed a reduced risk of slowness [OR per doubling increase: 0.84 (95% CI: 0.74, 0.96), OR in the highest (vs. lowest) quartile: 0.64 (95% CI: 0.47, 0.87), [Formula: see text]]. For linear regression models, MBzP quartiles were associated with slower walking speed ([Formula: see text]) at enrollment, whereas MEHHP quartiles were associated with slower walking speed, and MnBP quartiles were associated with faster walking speed in longitudinal analysis ([Formula: see text] and [Formula: see text] , respectively). Further, the BKMR analysis revealed negative overall trends between the phthalate metabolite mixtures and walking speed and DEHP group (MEHHP, MEOHP, and MECPP) had the main effect of the overall mixture. DISCUSSION: Urinary concentrations of prevalent phthalates exhibited significant associations with slow walking speed in adults ages 60–98 y. https://doi.org/10.1289/EHP10549
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spelling pubmed-100753112023-04-06 Urinary Phthalate Metabolites and Slow Walking Speed in the Korean Elderly Environmental Panel II Study Yoon, Jeonggyo García-Esquinas, Esther Kim, Junghoon Kwak, Jung Hyun Kim, Hongsoo Kim, Sungroul Kim, Kyoung-Nam Hong, Yun-Chul Choi, Yoon-Hyeong Environ Health Perspect Research BACKGROUND: Previous epidemiological studies have suggested that phthalate exposure may contribute to neurocognitive and neurobehavioral disorders and decreased muscle strength and bone mass, all of which may be associated with reduced physical performance. Walking speed is a reliable assessment tool for measuring physical performance in adults age 60 y and older. OBJECTIVE: We investigated associations between urinary phthalate metabolites and slowness of walking speed in community-dwelling adults ages 60–98 y. METHODS: We analyzed 1,190 older adults [range, 60–98 y of age; [Formula: see text] , [Formula: see text]] from the Korean Elderly Environmental Panel II study and measured repeatedly up to three times between 2012 and 2014. Phthalate exposure was estimated using the following phthalate metabolites in urine samples: mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-n-butyl phthalate (MnBP), mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), and mono-benzyl phthalate (MBzP). Slowness was defined as a walking speed of [Formula: see text]. We used logistic and linear regression models to evaluate the association between each urinary phthalate metabolite and slowness or walking-speed change. We also used Bayesian kernel machine regression (BKMR) to examine overall mixture effects on walking speed. RESULTS: At enrollment, MBzP levels were associated with an increased odds of slowness [odds ratio (OR) per doubling increase: 1.15, 95% confidence interval (CI): 1.02, 1.30; OR for the highest vs. lowest quartile: 2.20 (95% CI: 1.12, 4.35) with p-trend across [Formula: see text]]. In longitudinal analyses, MEHHP levels showed an increased risk of slowness [OR per doubling increase: 1.15 (95% CI: 1.02, 1.29), OR for the highest vs. lowest quartile: 1.47 (95% CI: 1.04, 2.06), [Formula: see text]]; whereas those with higher MnBP showed a reduced risk of slowness [OR per doubling increase: 0.84 (95% CI: 0.74, 0.96), OR in the highest (vs. lowest) quartile: 0.64 (95% CI: 0.47, 0.87), [Formula: see text]]. For linear regression models, MBzP quartiles were associated with slower walking speed ([Formula: see text]) at enrollment, whereas MEHHP quartiles were associated with slower walking speed, and MnBP quartiles were associated with faster walking speed in longitudinal analysis ([Formula: see text] and [Formula: see text] , respectively). Further, the BKMR analysis revealed negative overall trends between the phthalate metabolite mixtures and walking speed and DEHP group (MEHHP, MEOHP, and MECPP) had the main effect of the overall mixture. DISCUSSION: Urinary concentrations of prevalent phthalates exhibited significant associations with slow walking speed in adults ages 60–98 y. https://doi.org/10.1289/EHP10549 Environmental Health Perspectives 2023-04-05 /pmc/articles/PMC10075311/ /pubmed/37018009 http://dx.doi.org/10.1289/EHP10549 Text en https://ehp.niehs.nih.gov/about-ehp/licenseEHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted.
spellingShingle Research
Yoon, Jeonggyo
García-Esquinas, Esther
Kim, Junghoon
Kwak, Jung Hyun
Kim, Hongsoo
Kim, Sungroul
Kim, Kyoung-Nam
Hong, Yun-Chul
Choi, Yoon-Hyeong
Urinary Phthalate Metabolites and Slow Walking Speed in the Korean Elderly Environmental Panel II Study
title Urinary Phthalate Metabolites and Slow Walking Speed in the Korean Elderly Environmental Panel II Study
title_full Urinary Phthalate Metabolites and Slow Walking Speed in the Korean Elderly Environmental Panel II Study
title_fullStr Urinary Phthalate Metabolites and Slow Walking Speed in the Korean Elderly Environmental Panel II Study
title_full_unstemmed Urinary Phthalate Metabolites and Slow Walking Speed in the Korean Elderly Environmental Panel II Study
title_short Urinary Phthalate Metabolites and Slow Walking Speed in the Korean Elderly Environmental Panel II Study
title_sort urinary phthalate metabolites and slow walking speed in the korean elderly environmental panel ii study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10075311/
https://www.ncbi.nlm.nih.gov/pubmed/37018009
http://dx.doi.org/10.1289/EHP10549
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