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Early signs of cancer present in the fine detail of mammograms

The gist of abnormality can be rapidly extracted by medical experts from global information in medical images, such as mammograms, to identify abnormal mammograms with above-chance accuracy—even before any abnormalities are localizable. The current study evaluated the effect of different high-pass f...

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Autores principales: Raat, Emma M., Evans, Karla K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10075467/
https://www.ncbi.nlm.nih.gov/pubmed/37018164
http://dx.doi.org/10.1371/journal.pone.0282872
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author Raat, Emma M.
Evans, Karla K.
author_facet Raat, Emma M.
Evans, Karla K.
author_sort Raat, Emma M.
collection PubMed
description The gist of abnormality can be rapidly extracted by medical experts from global information in medical images, such as mammograms, to identify abnormal mammograms with above-chance accuracy—even before any abnormalities are localizable. The current study evaluated the effect of different high-pass filters on expert radiologists’ performance in detecting the gist of abnormality in mammograms, especially those acquired prior to any visibly actionable lesions. Thirty-four expert radiologists viewed unaltered and high-pass filtered versions of normal and abnormal mammograms. Abnormal mammograms consisted of obvious abnormalities, subtle abnormalities, and currently normal mammograms from women who would go to develop cancer in 2–3 years. Four levels of high-pass filtering were tested (0.5, 1, 1.5, and 2 cycles per degree (cpd) after brightening and contrast normalizing to the unfiltered mammograms. Overall performance for 0.5 and 1.5 did not change compared to unfiltered but was reduced for 1 and 2 cpd. Critically, filtering that eliminated frequencies below 0.5 and 1.5 cpd significantly boosted performance on mammograms acquired years prior appearance of localizable abnormalities. Filtering at 0.5 did not change the radiologist’s decision criteria compared to unfiltered mammograms whereas other filters resulted in more conservative ratings. The findings bring us closer to identifying the characteristics of the gist of the abnormal that affords radiologists detection of the earliest signs of cancer. A 0.5 cpd high-pass filter significantly boosts subtle, global signals of future cancerous abnormalities, potentially providing an image enhancement strategy for rapid assessment of impending cancer risk.
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spelling pubmed-100754672023-04-06 Early signs of cancer present in the fine detail of mammograms Raat, Emma M. Evans, Karla K. PLoS One Research Article The gist of abnormality can be rapidly extracted by medical experts from global information in medical images, such as mammograms, to identify abnormal mammograms with above-chance accuracy—even before any abnormalities are localizable. The current study evaluated the effect of different high-pass filters on expert radiologists’ performance in detecting the gist of abnormality in mammograms, especially those acquired prior to any visibly actionable lesions. Thirty-four expert radiologists viewed unaltered and high-pass filtered versions of normal and abnormal mammograms. Abnormal mammograms consisted of obvious abnormalities, subtle abnormalities, and currently normal mammograms from women who would go to develop cancer in 2–3 years. Four levels of high-pass filtering were tested (0.5, 1, 1.5, and 2 cycles per degree (cpd) after brightening and contrast normalizing to the unfiltered mammograms. Overall performance for 0.5 and 1.5 did not change compared to unfiltered but was reduced for 1 and 2 cpd. Critically, filtering that eliminated frequencies below 0.5 and 1.5 cpd significantly boosted performance on mammograms acquired years prior appearance of localizable abnormalities. Filtering at 0.5 did not change the radiologist’s decision criteria compared to unfiltered mammograms whereas other filters resulted in more conservative ratings. The findings bring us closer to identifying the characteristics of the gist of the abnormal that affords radiologists detection of the earliest signs of cancer. A 0.5 cpd high-pass filter significantly boosts subtle, global signals of future cancerous abnormalities, potentially providing an image enhancement strategy for rapid assessment of impending cancer risk. Public Library of Science 2023-04-05 /pmc/articles/PMC10075467/ /pubmed/37018164 http://dx.doi.org/10.1371/journal.pone.0282872 Text en © 2023 Raat, Evans https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Raat, Emma M.
Evans, Karla K.
Early signs of cancer present in the fine detail of mammograms
title Early signs of cancer present in the fine detail of mammograms
title_full Early signs of cancer present in the fine detail of mammograms
title_fullStr Early signs of cancer present in the fine detail of mammograms
title_full_unstemmed Early signs of cancer present in the fine detail of mammograms
title_short Early signs of cancer present in the fine detail of mammograms
title_sort early signs of cancer present in the fine detail of mammograms
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10075467/
https://www.ncbi.nlm.nih.gov/pubmed/37018164
http://dx.doi.org/10.1371/journal.pone.0282872
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