APOEε4 associates with microglial activation independently of Aβ plaques and tau tangles

Animal studies suggest that the apolipoprotein E ε4 (APOEε4) allele is a culprit of early microglial activation in Alzheimer’s disease (AD). Here, we tested the association between APOEε4 status and microglial activation in living individuals across the aging and AD spectrum. We studied 118 individu...

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Detalles Bibliográficos
Autores principales: Ferrari-Souza, João Pedro, Lussier, Firoza Z., Leffa, Douglas T., Therriault, Joseph, Tissot, Cécile, Bellaver, Bruna, Ferreira, Pâmela C. L., Malpetti, Maura, Wang, Yi-Ting, Povala, Guilherme, Benedet, Andréa L., Ashton, Nicholas J., Chamoun, Mira, Servaes, Stijn, Bezgin, Gleb, Kang, Min Su, Stevenson, Jenna, Rahmouni, Nesrine, Pallen, Vanessa, Poltronetti, Nina Margherita, O’Brien, John T., Rowe, James B., Cohen, Ann D., Lopez, Oscar L., Tudorascu, Dana L., Karikari, Thomas K., Klunk, William E., Villemagne, Victor L., Soucy, Jean-Paul, Gauthier, Serge, Souza, Diogo O., Zetterberg, Henrik, Blennow, Kaj, Zimmer, Eduardo R., Rosa-Neto, Pedro, Pascoal, Tharick A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10075966/
https://www.ncbi.nlm.nih.gov/pubmed/37018391
http://dx.doi.org/10.1126/sciadv.ade1474

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