ETV4 mediates dosage-dependent prostate tumor initiation and cooperates with p53 loss to generate prostate cancer

The mechanisms underlying ETS-driven prostate cancer initiation and progression remain poorly understood due to a lack of model systems that recapitulate this phenotype. We generated a genetically engineered mouse with prostate-specific expression of the ETS factor, ETV4, at lower and higher protein...

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Detalles Bibliográficos
Autores principales: Li, Dan, Zhan, Yu, Wang, Naitao, Tang, Fanying, Lee, Cindy J., Bayshtok, Gabriella, Moore, Amanda R., Wong, Elissa W. P., Pachai, Mohini R., Xie, Yuanyuan, Sher, Jessica, Zhao, Jimmy L., Khudoynazarova, Makhzuna, Gopalan, Anuradha, Chan, Joseph, Khurana, Ekta, Shepherd, Peter, Navone, Nora M., Chi, Ping, Chen, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10075989/
https://www.ncbi.nlm.nih.gov/pubmed/37018402
http://dx.doi.org/10.1126/sciadv.adc9446

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