The histone demethylase KDM5C controls female bone mass by promoting energy metabolism in osteoclasts

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Women experience osteoporosis at higher rates than men. Aside from hormones, the mechanisms driving sex-dependent bone mass regulation are not well understood. Here, we demonstrate that the X-linked H3K4me2/3 demethylase KDM5C regulates sex-specific bone mass. Loss of KDM5C in hematopoietic stem cel...

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Detalles Bibliográficos
Autores principales: Liu, Huadie, Zhai, Lukai, Liu, Ye, Lu, Di, Vander Ark, Alexandra, Yang, Tao, Krawczyk, Connie M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10075994/
https://www.ncbi.nlm.nih.gov/pubmed/37018401
http://dx.doi.org/10.1126/sciadv.adg0731

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