Synthesis and anti-SARS-CoV-2 evaluation of lipid prodrugs of β-D-N(4)-hydroxycytidine (NHC) and a 3′-fluoro-substituted analogue of NHC

β-D-N(4)-hydroxycytidine (NHC, EIDD-1931) is a nucleoside analogue that exhibits broad spectrum antiviral activity against a variety of RNA viruses. Herein, we report the synthesis of a series of lipid prodrugs of NHC and a novel 3′-fluoro modified NHC analogue, and evaluation of their antiviral act...

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Detalles Bibliográficos
Autores principales: Wen, Zhao-Hui, Wang, Meng-Meng, Li, Ling-Yun, Herdewijn, Piet, Snoeck, Robert, Andrei, Graciela, Liu, Zhao-Peng, Liu, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076076/
https://www.ncbi.nlm.nih.gov/pubmed/37031504
http://dx.doi.org/10.1016/j.bioorg.2023.106527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076076/
https://www.ncbi.nlm.nih.gov/pubmed/37031504
http://dx.doi.org/10.1016/j.bioorg.2023.106527

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