Perioperative Management of a Patient with Hemophilia C and Allergy to Fresh Frozen Plasma

Hemophilia C is a rare bleeding disorder characterized by a deficiency in clotting factor XI (fXI) and has no standard of care for preoperative optimization before cardiac surgery. Normalization of fXI levels in patients with hemophilia C can be achieved with fresh frozen plasma (FFP), which sometim...

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Detalles Bibliográficos
Autores principales: Kianian, Sara, Scorsese, Giacomo, Zabirowicz, Eric, Poppers, Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076113/
https://www.ncbi.nlm.nih.gov/pubmed/37034885
http://dx.doi.org/10.1155/2023/8973346
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author Kianian, Sara
Scorsese, Giacomo
Zabirowicz, Eric
Poppers, Jeremy
author_facet Kianian, Sara
Scorsese, Giacomo
Zabirowicz, Eric
Poppers, Jeremy
author_sort Kianian, Sara
collection PubMed
description Hemophilia C is a rare bleeding disorder characterized by a deficiency in clotting factor XI (fXI) and has no standard of care for preoperative optimization before cardiac surgery. Normalization of fXI levels in patients with hemophilia C can be achieved with fresh frozen plasma (FFP), which sometimes results in allergic reactions. We present a case of a patient with hemophilia C requiring coronary artery bypass grafting surgery who developed an allergic reaction to FFP. Our report underscores the balance between thrombosis and bleeding risks when devising a perioperative plan for patients with hemophilia C.
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spelling pubmed-100761132023-04-06 Perioperative Management of a Patient with Hemophilia C and Allergy to Fresh Frozen Plasma Kianian, Sara Scorsese, Giacomo Zabirowicz, Eric Poppers, Jeremy Case Rep Anesthesiol Case Report Hemophilia C is a rare bleeding disorder characterized by a deficiency in clotting factor XI (fXI) and has no standard of care for preoperative optimization before cardiac surgery. Normalization of fXI levels in patients with hemophilia C can be achieved with fresh frozen plasma (FFP), which sometimes results in allergic reactions. We present a case of a patient with hemophilia C requiring coronary artery bypass grafting surgery who developed an allergic reaction to FFP. Our report underscores the balance between thrombosis and bleeding risks when devising a perioperative plan for patients with hemophilia C. Hindawi 2023-03-29 /pmc/articles/PMC10076113/ /pubmed/37034885 http://dx.doi.org/10.1155/2023/8973346 Text en Copyright © 2023 Sara Kianian et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kianian, Sara
Scorsese, Giacomo
Zabirowicz, Eric
Poppers, Jeremy
Perioperative Management of a Patient with Hemophilia C and Allergy to Fresh Frozen Plasma
title Perioperative Management of a Patient with Hemophilia C and Allergy to Fresh Frozen Plasma
title_full Perioperative Management of a Patient with Hemophilia C and Allergy to Fresh Frozen Plasma
title_fullStr Perioperative Management of a Patient with Hemophilia C and Allergy to Fresh Frozen Plasma
title_full_unstemmed Perioperative Management of a Patient with Hemophilia C and Allergy to Fresh Frozen Plasma
title_short Perioperative Management of a Patient with Hemophilia C and Allergy to Fresh Frozen Plasma
title_sort perioperative management of a patient with hemophilia c and allergy to fresh frozen plasma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076113/
https://www.ncbi.nlm.nih.gov/pubmed/37034885
http://dx.doi.org/10.1155/2023/8973346
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