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Severe Lupus Myocarditis Preceded by Mesalazine-induced Lupus
In drug-induced lupus (DIL), symptoms similar to those of systemic lupus erythematosus (SLE) usually resolve after discontinuation of the offending drug. A 41-year-old-woman with a history of ulcerative colitis presented with polyarthritis and myositis and was positive for anti-double stranded (ds)...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Japanese Society of Internal Medicine
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076132/ https://www.ncbi.nlm.nih.gov/pubmed/35945022 http://dx.doi.org/10.2169/internalmedicine.9613-22 |
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author | Yamashita, Mai Nishimura, Keisuke Shirasugi, Iku Ichise, Yoshihide Ueda, Yo Saegusa, Jun |
author_facet | Yamashita, Mai Nishimura, Keisuke Shirasugi, Iku Ichise, Yoshihide Ueda, Yo Saegusa, Jun |
author_sort | Yamashita, Mai |
collection | PubMed |
description | In drug-induced lupus (DIL), symptoms similar to those of systemic lupus erythematosus (SLE) usually resolve after discontinuation of the offending drug. A 41-year-old-woman with a history of ulcerative colitis presented with polyarthritis and myositis and was positive for anti-double stranded (ds) DNA IgG antibody. After discontinuation of mesalazine, the symptoms resolved, and the antibody titer decreased. The patient was diagnosed with DIL. Six months later, lupus myocarditis developed. After treatment with glucocorticoids, cyclophosphamide, intravenous immunoglobulin, and an intra-aortic balloon pump, she showed dramatic improvement. Patients with DIL and an immunological predisposition, such as anti-dsDNA antibodies, may have SLE and should be carefully monitored. |
format | Online Article Text |
id | pubmed-10076132 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-100761322023-04-06 Severe Lupus Myocarditis Preceded by Mesalazine-induced Lupus Yamashita, Mai Nishimura, Keisuke Shirasugi, Iku Ichise, Yoshihide Ueda, Yo Saegusa, Jun Intern Med Case Report In drug-induced lupus (DIL), symptoms similar to those of systemic lupus erythematosus (SLE) usually resolve after discontinuation of the offending drug. A 41-year-old-woman with a history of ulcerative colitis presented with polyarthritis and myositis and was positive for anti-double stranded (ds) DNA IgG antibody. After discontinuation of mesalazine, the symptoms resolved, and the antibody titer decreased. The patient was diagnosed with DIL. Six months later, lupus myocarditis developed. After treatment with glucocorticoids, cyclophosphamide, intravenous immunoglobulin, and an intra-aortic balloon pump, she showed dramatic improvement. Patients with DIL and an immunological predisposition, such as anti-dsDNA antibodies, may have SLE and should be carefully monitored. The Japanese Society of Internal Medicine 2022-08-10 2023-03-15 /pmc/articles/PMC10076132/ /pubmed/35945022 http://dx.doi.org/10.2169/internalmedicine.9613-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Yamashita, Mai Nishimura, Keisuke Shirasugi, Iku Ichise, Yoshihide Ueda, Yo Saegusa, Jun Severe Lupus Myocarditis Preceded by Mesalazine-induced Lupus |
title | Severe Lupus Myocarditis Preceded by Mesalazine-induced Lupus |
title_full | Severe Lupus Myocarditis Preceded by Mesalazine-induced Lupus |
title_fullStr | Severe Lupus Myocarditis Preceded by Mesalazine-induced Lupus |
title_full_unstemmed | Severe Lupus Myocarditis Preceded by Mesalazine-induced Lupus |
title_short | Severe Lupus Myocarditis Preceded by Mesalazine-induced Lupus |
title_sort | severe lupus myocarditis preceded by mesalazine-induced lupus |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076132/ https://www.ncbi.nlm.nih.gov/pubmed/35945022 http://dx.doi.org/10.2169/internalmedicine.9613-22 |
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