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Severe Lupus Myocarditis Preceded by Mesalazine-induced Lupus

In drug-induced lupus (DIL), symptoms similar to those of systemic lupus erythematosus (SLE) usually resolve after discontinuation of the offending drug. A 41-year-old-woman with a history of ulcerative colitis presented with polyarthritis and myositis and was positive for anti-double stranded (ds)...

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Autores principales: Yamashita, Mai, Nishimura, Keisuke, Shirasugi, Iku, Ichise, Yoshihide, Ueda, Yo, Saegusa, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076132/
https://www.ncbi.nlm.nih.gov/pubmed/35945022
http://dx.doi.org/10.2169/internalmedicine.9613-22
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author Yamashita, Mai
Nishimura, Keisuke
Shirasugi, Iku
Ichise, Yoshihide
Ueda, Yo
Saegusa, Jun
author_facet Yamashita, Mai
Nishimura, Keisuke
Shirasugi, Iku
Ichise, Yoshihide
Ueda, Yo
Saegusa, Jun
author_sort Yamashita, Mai
collection PubMed
description In drug-induced lupus (DIL), symptoms similar to those of systemic lupus erythematosus (SLE) usually resolve after discontinuation of the offending drug. A 41-year-old-woman with a history of ulcerative colitis presented with polyarthritis and myositis and was positive for anti-double stranded (ds) DNA IgG antibody. After discontinuation of mesalazine, the symptoms resolved, and the antibody titer decreased. The patient was diagnosed with DIL. Six months later, lupus myocarditis developed. After treatment with glucocorticoids, cyclophosphamide, intravenous immunoglobulin, and an intra-aortic balloon pump, she showed dramatic improvement. Patients with DIL and an immunological predisposition, such as anti-dsDNA antibodies, may have SLE and should be carefully monitored.
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spelling pubmed-100761322023-04-06 Severe Lupus Myocarditis Preceded by Mesalazine-induced Lupus Yamashita, Mai Nishimura, Keisuke Shirasugi, Iku Ichise, Yoshihide Ueda, Yo Saegusa, Jun Intern Med Case Report In drug-induced lupus (DIL), symptoms similar to those of systemic lupus erythematosus (SLE) usually resolve after discontinuation of the offending drug. A 41-year-old-woman with a history of ulcerative colitis presented with polyarthritis and myositis and was positive for anti-double stranded (ds) DNA IgG antibody. After discontinuation of mesalazine, the symptoms resolved, and the antibody titer decreased. The patient was diagnosed with DIL. Six months later, lupus myocarditis developed. After treatment with glucocorticoids, cyclophosphamide, intravenous immunoglobulin, and an intra-aortic balloon pump, she showed dramatic improvement. Patients with DIL and an immunological predisposition, such as anti-dsDNA antibodies, may have SLE and should be carefully monitored. The Japanese Society of Internal Medicine 2022-08-10 2023-03-15 /pmc/articles/PMC10076132/ /pubmed/35945022 http://dx.doi.org/10.2169/internalmedicine.9613-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Yamashita, Mai
Nishimura, Keisuke
Shirasugi, Iku
Ichise, Yoshihide
Ueda, Yo
Saegusa, Jun
Severe Lupus Myocarditis Preceded by Mesalazine-induced Lupus
title Severe Lupus Myocarditis Preceded by Mesalazine-induced Lupus
title_full Severe Lupus Myocarditis Preceded by Mesalazine-induced Lupus
title_fullStr Severe Lupus Myocarditis Preceded by Mesalazine-induced Lupus
title_full_unstemmed Severe Lupus Myocarditis Preceded by Mesalazine-induced Lupus
title_short Severe Lupus Myocarditis Preceded by Mesalazine-induced Lupus
title_sort severe lupus myocarditis preceded by mesalazine-induced lupus
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076132/
https://www.ncbi.nlm.nih.gov/pubmed/35945022
http://dx.doi.org/10.2169/internalmedicine.9613-22
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