Oncogenic CALR mutant C-terminus mediates dual binding to the thrombopoietin receptor triggering complex dimerization and activation

Calreticulin (CALR) frameshift mutations represent the second cause of myeloproliferative neoplasms (MPN). In healthy cells, CALR transiently and non-specifically interacts with immature N-glycosylated proteins through its N-terminal domain. Conversely, CALR frameshift mutants turn into rogue cytoki...

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Detalles Bibliográficos
Autores principales: Papadopoulos, Nicolas, Nédélec, Audrey, Derenne, Allison, Şulea, Teodor Asvadur, Pecquet, Christian, Chachoua, Ilyas, Vertenoeil, Gaëlle, Tilmant, Thomas, Petrescu, Andrei-Jose, Mazzucchelli, Gabriel, Iorga, Bogdan I., Vertommen, Didier, Constantinescu, Stefan N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076285/
https://www.ncbi.nlm.nih.gov/pubmed/37019903
http://dx.doi.org/10.1038/s41467-023-37277-3

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