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Post-reperfusion acute MR diffusion in stroke is a potential predictor for clinical outcome in rats

Middle cerebral artery occlusion (MCAO) models show substantial variability in outcome, introducing uncertainties in the evaluation of treatment effects. Early outcome predictors would be essential for prognostic purposes and variability control. We aimed to compare apparent diffusion coefficient (A...

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Autores principales: Nagy, Szilvia Anett, Ivic, Ivan, Tóth, Péter, Komoly, Sámuel, Kiss, Tamás, Pénzes, Máté, Málnási-Csizmadia, András, Dóczi, Tamás, Perlaki, Gábor, Orsi, Gergely
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076321/
https://www.ncbi.nlm.nih.gov/pubmed/37019923
http://dx.doi.org/10.1038/s41598-023-32679-1
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author Nagy, Szilvia Anett
Ivic, Ivan
Tóth, Péter
Komoly, Sámuel
Kiss, Tamás
Pénzes, Máté
Málnási-Csizmadia, András
Dóczi, Tamás
Perlaki, Gábor
Orsi, Gergely
author_facet Nagy, Szilvia Anett
Ivic, Ivan
Tóth, Péter
Komoly, Sámuel
Kiss, Tamás
Pénzes, Máté
Málnási-Csizmadia, András
Dóczi, Tamás
Perlaki, Gábor
Orsi, Gergely
author_sort Nagy, Szilvia Anett
collection PubMed
description Middle cerebral artery occlusion (MCAO) models show substantial variability in outcome, introducing uncertainties in the evaluation of treatment effects. Early outcome predictors would be essential for prognostic purposes and variability control. We aimed to compare apparent diffusion coefficient (ADC) MRI data obtained during MCAO and shortly after reperfusion for their potentials in acute-phase outcome prediction. Fifty-nine male rats underwent a 45-min MCAO. Outcome was defined in three ways: 21-day survival; 24 h midline-shift and neurological scores. Animals were divided into two groups: rats surviving 21 days after MCAO (survival group, n = 46) and rats dying prematurely (non-survival/NS group, n = 13). At reperfusion, NS group showed considerably larger lesion volume and lower mean ADC of the initial lesion site (p < 0.0001), while during occlusion there were no significant group differences. At reperfusion, each survival animal showed decreased lesion volume and increased mean ADC of the initial lesion site compared to those during occlusion (p < 10(–6)), while NS group showed a mixed pattern. At reperfusion, lesion volume and mean ADC of the initial lesion site were significantly associated with 24 h midline-shift and neurological scores. Diffusion MRI performed soon after reperfusion has a great impact in early-phase outcome prediction, and it works better than the measurement during occlusion.
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spelling pubmed-100763212023-04-07 Post-reperfusion acute MR diffusion in stroke is a potential predictor for clinical outcome in rats Nagy, Szilvia Anett Ivic, Ivan Tóth, Péter Komoly, Sámuel Kiss, Tamás Pénzes, Máté Málnási-Csizmadia, András Dóczi, Tamás Perlaki, Gábor Orsi, Gergely Sci Rep Article Middle cerebral artery occlusion (MCAO) models show substantial variability in outcome, introducing uncertainties in the evaluation of treatment effects. Early outcome predictors would be essential for prognostic purposes and variability control. We aimed to compare apparent diffusion coefficient (ADC) MRI data obtained during MCAO and shortly after reperfusion for their potentials in acute-phase outcome prediction. Fifty-nine male rats underwent a 45-min MCAO. Outcome was defined in three ways: 21-day survival; 24 h midline-shift and neurological scores. Animals were divided into two groups: rats surviving 21 days after MCAO (survival group, n = 46) and rats dying prematurely (non-survival/NS group, n = 13). At reperfusion, NS group showed considerably larger lesion volume and lower mean ADC of the initial lesion site (p < 0.0001), while during occlusion there were no significant group differences. At reperfusion, each survival animal showed decreased lesion volume and increased mean ADC of the initial lesion site compared to those during occlusion (p < 10(–6)), while NS group showed a mixed pattern. At reperfusion, lesion volume and mean ADC of the initial lesion site were significantly associated with 24 h midline-shift and neurological scores. Diffusion MRI performed soon after reperfusion has a great impact in early-phase outcome prediction, and it works better than the measurement during occlusion. Nature Publishing Group UK 2023-04-05 /pmc/articles/PMC10076321/ /pubmed/37019923 http://dx.doi.org/10.1038/s41598-023-32679-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Nagy, Szilvia Anett
Ivic, Ivan
Tóth, Péter
Komoly, Sámuel
Kiss, Tamás
Pénzes, Máté
Málnási-Csizmadia, András
Dóczi, Tamás
Perlaki, Gábor
Orsi, Gergely
Post-reperfusion acute MR diffusion in stroke is a potential predictor for clinical outcome in rats
title Post-reperfusion acute MR diffusion in stroke is a potential predictor for clinical outcome in rats
title_full Post-reperfusion acute MR diffusion in stroke is a potential predictor for clinical outcome in rats
title_fullStr Post-reperfusion acute MR diffusion in stroke is a potential predictor for clinical outcome in rats
title_full_unstemmed Post-reperfusion acute MR diffusion in stroke is a potential predictor for clinical outcome in rats
title_short Post-reperfusion acute MR diffusion in stroke is a potential predictor for clinical outcome in rats
title_sort post-reperfusion acute mr diffusion in stroke is a potential predictor for clinical outcome in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076321/
https://www.ncbi.nlm.nih.gov/pubmed/37019923
http://dx.doi.org/10.1038/s41598-023-32679-1
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