A stress-induced cilium-to-PML-NB route drives senescence initiation

Cellular senescence contributes to tissue homeostasis and age-related pathologies. However, how senescence is initiated in stressed cells remains vague. Here, we discover that exposure to irradiation, oxidative or inflammatory stressors induces transient biogenesis of primary cilia, which are then u...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Xiaoyu, Zhang, Yingyi, Zhang, Yuanyuan, Zhang, Xu, Huang, Yan, He, Kai, Chen, Chuan, Hao, Jielu, Zhao, Debiao, LeBrasseur, Nathan K., Kirkland, James L., Chini, Eduardo N., Wei, Qing, Ling, Kun, Hu, Jinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076330/
https://www.ncbi.nlm.nih.gov/pubmed/37019904
http://dx.doi.org/10.1038/s41467-023-37362-7

Ejemplares similares

Ejemplares similares