Fifty years on: Serotonin and depression

It has been over 50 years since the original serotonin hypothesis was proposed by the British Psychiatrist Alec Coppen. Recently, some authors have questioned the validity of the hypothesis. In this narrative review, we summarise the evidence for the serotonin hypothesis of depression, focusing on p...

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Detalles Bibliográficos
Autores principales: Jauhar, Sameer, Cowen, Philip J, Browning, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076339/
https://www.ncbi.nlm.nih.gov/pubmed/36938996
http://dx.doi.org/10.1177/02698811231161813
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author Jauhar, Sameer
Cowen, Philip J
Browning, Michael
author_facet Jauhar, Sameer
Cowen, Philip J
Browning, Michael
author_sort Jauhar, Sameer
collection PubMed
description It has been over 50 years since the original serotonin hypothesis was proposed by the British Psychiatrist Alec Coppen. Recently, some authors have questioned the validity of the hypothesis. In this narrative review, we summarise the evidence for the serotonin hypothesis of depression, focusing on psychopharmacology and molecular imaging, as well as systems-level neuroscience.
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spelling pubmed-100763392023-04-07 Fifty years on: Serotonin and depression Jauhar, Sameer Cowen, Philip J Browning, Michael J Psychopharmacol Perspectives It has been over 50 years since the original serotonin hypothesis was proposed by the British Psychiatrist Alec Coppen. Recently, some authors have questioned the validity of the hypothesis. In this narrative review, we summarise the evidence for the serotonin hypothesis of depression, focusing on psychopharmacology and molecular imaging, as well as systems-level neuroscience. SAGE Publications 2023-03-20 2023-03 /pmc/articles/PMC10076339/ /pubmed/36938996 http://dx.doi.org/10.1177/02698811231161813 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Perspectives
Jauhar, Sameer
Cowen, Philip J
Browning, Michael
Fifty years on: Serotonin and depression
title Fifty years on: Serotonin and depression
title_full Fifty years on: Serotonin and depression
title_fullStr Fifty years on: Serotonin and depression
title_full_unstemmed Fifty years on: Serotonin and depression
title_short Fifty years on: Serotonin and depression
title_sort fifty years on: serotonin and depression
topic Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076339/
https://www.ncbi.nlm.nih.gov/pubmed/36938996
http://dx.doi.org/10.1177/02698811231161813
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