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Candidate 3-benzazepine-1-ol type GluN2B receptor radioligands ((11)C-NR2B-Me enantiomers) have high binding in cerebellum but not to σ1 receptors

INTRODUCTION: We recently reported (11)C-NR2B-SMe ([S-methyl-(11)C](R,S)-7-thiomethoxy-3-(4-(4-methyl-phenyl)butyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ol) and its enantiomers as candidate radioligands for imaging the GluN2B subunit within rat N-methyl-D-aspartate receptors. However, these radiol...

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Detalles Bibliográficos
Autores principales:	Cai, Lisheng, Liow, Jeih-San, Morse, Cheryl L., Telu, Sanjay, Davies, Riley, Manly, Lester S., Zoghbi, Sami S., Chin, Frederick T., Innis, Robert B., Pike, Victor W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076467/ https://www.ncbi.nlm.nih.gov/pubmed/37017827 http://dx.doi.org/10.1186/s13550-023-00975-6

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