Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea

Four new 14(13 → 12)-abeolanostane triterpenoids featuring extended π-conjugated systems, kadcoccitanes E–H (1–4), were obtained from the stems of Kadsura coccinea through using a HPLC − UV-guided approach. Their structural and configurational determination was accomplished through extensive spectro...

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Detalles Bibliográficos
Autores principales: Zhang, Qi-Qi, Hu, Kun, Sun, Han-Dong, Puno, Pema-Tenzin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076471/
https://www.ncbi.nlm.nih.gov/pubmed/37020130
http://dx.doi.org/10.1007/s13659-023-00376-1
Descripción
Sumario:Four new 14(13 → 12)-abeolanostane triterpenoids featuring extended π-conjugated systems, kadcoccitanes E–H (1–4), were obtained from the stems of Kadsura coccinea through using a HPLC − UV-guided approach. Their structural and configurational determination was accomplished through extensive spectroscopic analysis coupled with quantum chemical calculations. Kadcoccitanes E–H were tested for their cytotoxic activities against five human tumor cell lines (HL-60, A-549, SMMC-7721, MDA-MB-231, SW-480) but none of them exhibited activities at the concentration 40 μM. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-023-00376-1.

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